ATP-Binding Cassette (ABC) transporters are important mediators of multidrug resistance
(MDR) in patients with cancer. Although their role in MDR has been extensively studied in …

A key issue in the treatment of many cancers is the development of resistance to
chemotherapeutic drugs. Resistance mechanisms are numerous and complex. One of them …

Multidrug resistance (MDR) is a major problem in cancer chemotherapy. One of the best
known mechanisms of MDR is the elevated expression of ATP-binding cassette (ABC) …

Different mechanisms of drug resistance, including ATP-binding cassette (ABC) transporters,
are responsible for treatment failure of tumors. We developed a low-density DNA microarray …

The expression of ATP-binding cassette transporter (ABC transporters) has been reported in
various tissues such as the lung, liver, kidney, brain and intestine. These proteins account …

The adenosine triphosphate binding cassette (ABC) transporters are one of the largest
transmembrane gene families in humans. The ABC transporters are present in a number of …

The development of multidrug resistance (MDR) to chemotherapy remains a major
challenge in the treatment of cancer. Resistance exists against every effective anticancer …

For analysis of multidrug resistance, a major barrier to effective cancer chemotherapy, we
profiled mRNA expression of the 48 known human ABC transporters in 60 diverse cancer …

ATP-binding cassette (ABC) genes play a role in the resistance of malignant cells to
anticancer agents. The ABC gene products, including ABCB1 (P-glycoprotein), ABCC1 …

Multidrug transporter proteins are best known for their contributions to chemoresistance
through the efflux of anticancer drugs from cancer cells. However, a considerable body of …