Endothelins (ET) are 21-aminoacid peptides produced in many different tissues. They were
discovered as a product of vascular endothelial cells (69), but have since been shown to be …

The normal functional state of the vasculature and the events leading to the development of
significant arterial disease involve the interaction of important vasoactive substances, which …

Since its identification in 1988, 1 endothelin has attracted intensive interdisciplinary
research interest because of itsunique profile as an endo-thelium-derived vasoactive factor …

Abstract The endothelins (ET) are 21-amino-acid peptides produced by endothelial cells
and many other tissues [1]. Three isoforms of ET have been characterized (ET-1, 2 and 3) …

Endothelin-1 (ET-1) is a peptide consisting of 21 amino acids. It was originally isolated from
media conditioned by cultured vascular endothelial cells.'Three isopeptides (ET-1, 2, and 3) …

The endothelins (ETs) are regulatory peptides, distributed in many organ systems and with
potent physiological effects. ETs represent the most powerful vasoconstrictive substances …

Endothelin was isolated and identified in 1988 by Yanagisawa et al. The endothelin family
consists of 21 amino acid isoforms endothelin-1, endothelin-2 and endothelin-3. Endothelin …

Endothelin-1 (ET-1) was originally isolated in 1988 as a secretory product of cultured
porcine aortic endothelial cells (Yanagisawa et a/., 1988) and was shown to be a potent …

Background Endothelin-1 (ET-1) has been shown to exist in many organs and to have
various biologic functions including vasoconstriction. However, an exact location of ET gene …

Abstract The endothelins, 21-amino-acid peptides produced by the endothelium of blood
vessels and many other tissues such as the kidney, brain, endocrine organs, etc., are potent …