Acute lymphoblastic leukemia (ALL) in infants is characterized by a high frequency of MLL
gene rearrangements. By contrast, the t (12; 21) ETV6–RUNX1 fusion gene is typically …

Abstract Background Both ETV6–RUNX1 (TEL–AML1) fusion and hyperdiploidy (> 50
chromosomes) in transformed lymphoblasts are favorable genetic features in childhood …

Monozygotic twin pairs with concordant ALL have provided unique insights into the
molecular pathogenesis and natural history of childhood leukaemia. Data from twin pair …

Pediatric acute lymphoblastic leukemia (ALL) is defined by recurrent chromosomal
aberrations including hyperdiploidy and chromosomal translocations. Many of these …

Acute lymphoblastic leukemia (ALL), the most common malignant disorder in childhood, is
typically associated with numerical chromosomal aberrations, fusion genes or small focal …

Abstract The t (12; 21)(p13; q22) translocation is the most frequently occurring single genetic
abnormality in pediatric leukemia. This translocation results in the fusion of the ETV6 and …

The leukemia‐associated ETV6‐RUNX1‐translocation frequently emerges prenatally.
Reverse‐transcriptase PCR screening may indicate presence of ETV6‐RUNX1 transcripts in …

The ETV6/RUNX1 fusion gene, present in 25% of B-lineage childhood acute lymphoblastic
leukemia (ALL), is thought to represent an initiating event, which requires additional genetic …

With an incidence of approximately 25%, the ETV6-RUNX1 (ER) gene fusion is the most
common primary acquired genetic aberration in childhood B-cell precursor acute …

Acute leukaemia is the major subtype of paediatric cancer with a cumulative risk of 1 in 2000
for children up to the age of 15 years. Childhood acute lymphoblastic leukaemia (ALL) is a …