Lung adenocarcinoma (LUAD) harboring EGFR mutations prevails in Asian population.
However, the inter-patient and intra-tumor heterogeneity has not been addressed at single …

Methods We used single-cell transcriptome sequencing and multiplex
immunohistochemistry to investigate the immune microenvironment of EGFR-mutant and …

Chinese lung cancer patients have distinct epidemiologic and genomic features,
highlighting the presence of specific etiologic mechanisms other than smoking. Here, we …

Background Understanding the genomic landscape and immune microenvironment features
of preinvasive and early invasive lung adenocarcinoma may provide critical insight and …

Background Lung adenocarcinoma (LUAD) patients with different American Joint Committee
on Cancer stages have different overall 5‐year survival rates. The tumor microenvironment …

EGFR-mutant lung adenocarcinomas (LUAD) display diverse clinical trajectories and are
characterized by rapid but short-lived responses to EGFR tyrosine kinase inhibitors (TKIs) …

Deep understanding of the genomic and immunological differences between Chinese and
Western lung cancer patients is of great importance for target therapy selection and …

Lung cancer is a highly heterogeneous disease. Cancer cells and cells within the tumor
microenvironment together determine disease progression, as well as response to or …

Background Extensive research has established the significant correlations between cancer-
associated fibroblasts (CAFs) and various stages of cancer development, including initiation …

ABSTRACT Background Lung adenocarcinomas (LUADs) lead to the majority of deaths
attributable to lung cancer. We performed whole-exome sequencing (WES) and immune …