Identification of a partial and selective TRPV1 agonist CPIPC for alleviation of inflammatory pain

L Dong, Q Zhou, Q Liang, Z Qiao, Y Liu, L Shao… - Molecules, 2022 - mdpi.com
Transient receptor potential vanilloid 1 (TRPV1) is a non-selective cation channel,
predominantly expressed in a subset of peripheral sensory neurons for pain signaling …

[HTML][HTML] Novel TRPV1 channel agonists with faster and more potent analgesic properties than capsaicin

Y Duarte, J Cáceres, RV Sepúlveda… - Frontiers in …, 2020 - frontiersin.org
The transient receptor potential vanilloid 1 (TRPV1) ion channel is a member of the family of
Transient Receptor Potential (TRP) channels that acts as a molecular detector of noxious …

[HTML][HTML] Design and characterization of a noncompetitive antagonist of the transient receptor potential vanilloid subunit 1 channel with in vivo analgesic and anti …

C García-Martínez, A Fernández-Carvajal… - The Journal of …, 2006 - Elsevier
Vanilloid receptor subunit 1 (TRPV1) is an integrator of physical and chemical stimuli in the
peripheral nervous system. This receptor plays a key role in the pathophysiology of …

TRPV1-targeted drugs in development for human pain conditions

M Iftinca, M Defaye, C Altier - Drugs, 2021 - Springer
The transient receptor potential vanilloid-1 (TRPV1) is a non-specific cation channel known
for its sensitivity to pungent vanilloid compound (ie capsaicin) and noxious stimuli, including …

TRPV1 gain-of-function mutation impairs pain and itch sensations in mice

L Duo, L Hu, N Tian, G Cheng, H Wang, Z Lin… - Molecular …, 2018 - journals.sagepub.com
Transient receptor potential vanilloid 1 (TRPV1) is a non-selective cation channel, which can
detect various noxious stimuli that cause pain, inflammation, hyperalgesia, and itch. TRPV1 …

Transient receptor potential vanilloid 1 channel modulation: a novel approach to pain therapy

VL Korlipara - Current Bioactive Compounds, 2008 - ingentaconnect.com
The TRPV1 vanilloid receptor, first cloned and characterized in 1997, is a non-selective
cation channel expressed in primary sensory neurons, and is a key pain sensor and …

Synthesis and pharmacology of (pyridin-2-yl) methanol derivatives as novel and selective transient receptor potential vanilloid 3 antagonists

A Gomtsyan, RG Schmidt, EK Bayburt… - Journal of medicinal …, 2016 - ACS Publications
Transient receptor potential vanilloid 3 (TRPV3) is a Ca2+-and Na+-permeable channel with
a unique expression pattern. TRPV3 is found in both neuronal and non-neuronal tissues …

TRPV1 agonist approaches for pain management

KR Bley - Vanilloid receptor TRPV1 in drug discovery: targeting …, 2010 - Wiley Online Library
Capsaicin and other naturally occurring pungent molecules have been used for centuries as
topical analgesics to treat a variety of painful conditions. However, only within the last 12 …

Preclinical characterization of three transient receptor potential vanilloid receptor 1 antagonists for early use in human intradermal microdose analgesic studies

E Sjögren, MM Halldin, O Stålberg… - … Journal of Pain, 2018 - Wiley Online Library
Background The transient receptor potential vanilloid receptor 1 (TRPV 1) is a nonselective
cation channel involved in the mediation of peripheral pain to the central nervous system. As …

TRPV1: a target for rational drug design

V Carnevale, T Rohacs - Pharmaceuticals, 2016 - mdpi.com
Transient Receptor Potential Vanilloid 1 (TRPV1) is a non-selective, Ca2+ permeable cation
channel activated by noxious heat, and chemical ligands, such as capsaicin and …