With 462 reviews over the past decade, Transient Receptor Potential (TRP) channels
arguably represent one of today's most extensively reviewed pharmacological targets. The …

Importance of the field: Transient receptor potential vanilloid-1 (TRPV1, vanilloid receptor-1)
is a nonspecific cation channel that can be activated by multiple endogenous stimuli and by …

Transient receptor potential vanilloid 1 (TRPV1) antagonists can inhibit the transmission of
nociceptive signals from the peripheral to the central nervous system (CNS), providing a …

TRPV1, a member of the transient receptor potential (TRP) family, is a nonselective calcium
permeable ion channel gated by physical and chemical stimuli. In the skin, TRPV1 plays an …

Paradoxically, some TRPV1 agonists are, at the organismal level, both nonpungent and
clinically useful as topical analgesics. Here, we describe the scaled-up synthesis and …

Pharmacological modulation of the transient receptor potential vanilloid‐1 (TRPV1) receptor
function offers a promising means of producing pain relief at the level of the primary sensory …

Transient receptor potential vanilloid 1 (TRPV1) is primarily expressed in central and
peripheral terminals of non-myelinated primary afferent neurons. We previously showed that …

Transient receptor potential vanilloid type 1 (TRPV1), a ligand-gated cation channel, is a
polymodal nocitransducer widely expressed within pain transmitting/modulating areas of the …

The transient receptor potential vanilloid 1 (TRPV1) channel is a polymodal receptor in
sensory nerves and involved in pain sensation. TRPV1 has at least three distinct activation …

The capsaicin receptor, transient receptor potential vanilloid type 1 ion channel (TRPV1),
has been identified as a polymodal transducer molecule on a sub-set of primary sensory …