Compulsive behaviors have been associated with striatal hyperactivity. Parvalbumin-
positive striatal interneurons (PVIs) in the striatum play a crucial role in regulating striatal …

Excessive grooming of Sapap3-KO mice has been used as a model of obsessive-
compulsive disorder (OCD). Previous studies suggest that dysregulation of cortico-striatal …

Compulsive behaviors are a hallmark symptom of obsessive compulsive disorder (OCD).
Striatal hyperactivity has been linked to compulsive behavior generation in correlative …

Self-grooming is an innate, naturalistic behavior found in a wide variety of organisms. The
control of rodent grooming has been shown to be mediated by the dorsolateral striatum …

Abstract Obsessive-Compulsive Disorder (OCD), characterized by intrusive thoughts
(obsessions) and repetitive behaviors (compulsions), is associated with dysfunction in fronto …

Background Deep brain stimulation (DBS) is an effective treatment for patients with
obsessive-compulsive disorder (OCD) that do not respond to conventional therapies …

Compulsive behaviors are a hallmark symptom of obsessive compulsive disorder (OCD).
Striatal hyperactivity has been linked to compulsive behavior generation in correlative …

Dysfunctions in frontostriatal brain circuits have been implicated in neuropsychiatric
disorders, including those characterized by the presence of repetitive behaviors. We …

Obsessive-compulsive disorder (OCD) is a circuit disorder involving corticostriatal
projections, which play a role in motor control. The Sapap3-knockout (KO) mouse is a …

Obsessive compulsive disorder (OCD) is associated with disruption of sensorimotor gating,
which may contribute to difficulties inhibiting intrusive thoughts and compulsive rituals …