Exogenous BH4 (tetrahydrobiopterin) has been shown to improve endothelial function in
cardiovascular disease; however, in the presence of elevated superoxide levels and …

An elevation of oxidized forms of tetrahydrobiopterin (BH4), especially dihydrobiopterin
(BH2), has been reported in the setting of oxidative stress, such as arteriosclerotic …

Conditions associated with impaired nitric oxide (NO) activity and accelerated
atherosclerosis have been shown to be associated with a reduced bioavailability of …

To investigate the role of tetrahydrobiopterin (BH4), an essential cofactor of nitric oxide
synthase, in endothelial function in a model of genetic hypertension, acetylcholine-and …

Objective The pteridine cofactor tetrahydrobiopterin (BH4) has emerged as a critical
determinant of endothelial nitric oxide synthase (eNOS) activity. When BH4 availability is …

Background: A deficiency of tetrahydrobiopterin (BH4), an essential cofactor for nitric oxide
(NO) synthase, decreases NO synthesis and increases superoxide production …

Tetrahydrobiopterin (BH 4) is an essential cofactor for nitric oxide synthase (NOS) and a
scavenger of oxygen-derived free radicals. Decreased availability of BH 4 leads, under in …

Background—Tetrahydrobiopterin (BH4), an essential cofactor for the synthesis of NO,
improves endothelial dysfunction after ischemia/reperfusion. Therefore, we hypothesized …

OBJECTIVES We sought to test whether tetrahydrobiopterin (BH4) supplementation
improves nitric oxide (NO) bioactivity in smokers. BACKGROUND In smokers, endothelium …

Objective—Inducible nitric oxide synthase (iNOS) is expressed in arteries during
inflammation and may contribute to vascular dysfunction. Effects of gene transfer of iNOS to …