An anti-RANKL treatment reduces muscle inflammation and dysfunction and strengthens bone in dystrophic mice

D Hamoudi, L Marcadet… - Human Molecular …, 2019 - academic.oup.com
Duchenne muscular dystrophy (DMD) is the most severe form of muscular dystrophy which
leads to progressive muscle degeneration and inflammation. The receptor activator of …

Anti-RANKL therapy prevents glucocorticoid-induced bone loss and promotes muscle function in a mouse model of Duchenne muscular dystrophy

SN Jayash, D Hamoudi, LA Stephen, A Argaw… - Calcified Tissue …, 2023 - Springer
Bisphosphonates prevent bone loss in glucocorticoid (GC)-treated boys with Duchenne
muscular dystrophy (DMD) and are recommended as standard of care. Targeting receptor …

Genetic deletion of muscle RANK or selective inhibition of RANKL is not as effective as full-length OPG-fc in mitigating muscular dystrophy

SS Dufresne, A Boulanger-Piette, S Bossé… - Acta Neuropathologica …, 2018 - Springer
Although there is a strong association between osteoporosis and skeletal muscle
atrophy/dysfunction, the functional relevance of a particular biological pathway that …

RANKL inhibition improves muscle strength and insulin sensitivity and restores bone mass

N Bonnet, L Bourgoin, E Biver, E Douni… - The Journal of …, 2023 - Am Soc Clin Investig
Receptor activator of NF-κB ligand (RANKL) activates, while osteoprotegerin (OPG) inhibits,
osteoclastogenesis. A neutralizing Ab against RANKL, denosumab, improves bone strength …

RANKL inhibition improves muscle strength and insulin sensitivity and restores bone mass

N Bonnet, L Bourgoin, E Biver, E Douni… - The Journal of …, 2020 - Am Soc Clin Investig
Receptor activator of NF-κB ligand (RANKL) activates, while osteoprotegerin (OPG) inhibits,
osteoclastogenesis. A neutralizing Ab against RANKL, denosumab, improves bone strength …

[HTML][HTML] Interplay of IKK/NF-κB signaling in macrophages and myofibers promotes muscle degeneration in Duchenne muscular dystrophy

S Acharyya, SA Villalta, N Bakkar… - The Journal of …, 2007 - Am Soc Clin Investig
Duchenne muscular dystrophy (DMD) is a lethal X-linked disorder associated with
dystrophin deficiency that results in chronic inflammation and severe skeletal muscle …

Nuclear factor kappa-B blockade reduces skeletal muscle degeneration and enhances muscle function in Mdx mice

S Messina, A Bitto, M Aguennouz, L Minutoli… - Experimental …, 2006 - Elsevier
Duchenne muscular dystrophy (DMD) is a progressive muscle-wasting disease due to a
mutation in the dystrophin gene and the consequential protein deficiency in muscle. How the …

Osteopontin promotes fibrosis in dystrophic mouse muscle by modulating immune cell subsets and intramuscular TGF-β

SA Vetrone, E Montecino-Rodriguez… - The Journal of …, 2009 - Am Soc Clin Investig
Duchenne muscular dystrophy (DMD) is an X-linked, degenerative muscle disease that is
exacerbated by secondary inflammation. Here, we characterized the immunological milieu …

Muscle weakness and selective muscle atrophy in osteoprotegerin-deficient mice

D Hamoudi, Z Bouredji, L Marcadet… - Human Molecular …, 2020 - academic.oup.com
Bone and muscle are tightly coupled and form a functional unit under normal conditions. The
receptor-activator of nuclear factor κB/receptor-activator of nuclear factor κB …

Targeting the muscle-bone unit: filling two needs with one deed in the treatment of Duchenne muscular dystrophy

A Boulanger Piette, D Hamoudi, L Marcadet… - Current osteoporosis …, 2018 - Springer
Abstract Purpose of Review In Duchenne muscular dystrophy (DMD), the progressive
skeletal and cardiac muscle dysfunction and degeneration is accompanied by low bone …