Iminodibenzyl redirected cyclooxygenase-2 catalyzed dihomo-γ-linolenic acid peroxidation pattern in lung cancer
Abstract Cyclooxygenase-2 (COX-2) is up-regulated by redox imbalance and is considered
a target for cancer therapy. The rationale of the COX-2 inhibitor lies in suppressing COX-2 …
a target for cancer therapy. The rationale of the COX-2 inhibitor lies in suppressing COX-2 …
Knockdown of delta-5-desaturase promotes the anti-cancer activity of dihomo-γ-linolenic acid and enhances the efficacy of chemotherapy in colon cancer cells …
Cyclooxygenase (COX), commonly overexpressed in cancer cells, is a major lipid
peroxidizing enzyme that metabolizes polyunsaturated fatty acids (ω-3s and ω-6s). The COX …
peroxidizing enzyme that metabolizes polyunsaturated fatty acids (ω-3s and ω-6s). The COX …
[HTML][HTML] Free radical derivatives formed from cyclooxygenase-catalyzed dihomo-γ-linolenic acid peroxidation can attenuate colon cancer cell growth and enhance 5 …
Dihomo-γ-linolenic acid (DGLA) and its downstream fatty acid arachidonic acid (AA) are
both nutritionally important ω–6 polyunsaturated fatty acids (ω–6s). Evidence shows that, via …
both nutritionally important ω–6 polyunsaturated fatty acids (ω–6s). Evidence shows that, via …
Knockdown delta-5-desaturase promotes the formation of a novel free radical byproduct from COX-catalyzed ω-6 peroxidation to induce apoptosis and sensitize …
Recent research has demonstrated that colon cancer cell proliferation can be suppressed in
the cells that overexpress COX-2 via generating 8-hydroxyoctanoic acid (a free radical …
the cells that overexpress COX-2 via generating 8-hydroxyoctanoic acid (a free radical …
Knocking Down Delta-5 Desaturase and Exploiting High Expression Level of COX-2 to Inhibit Cancer Migration and Invasion
Our recent research has shown that knockdown of delta-5 desaturase (D5D, a key enzyme
that converts dihomo-γ-linolenic acid to arachidonic acid) and treatment dihomo-γ-linolenic …
that converts dihomo-γ-linolenic acid to arachidonic acid) and treatment dihomo-γ-linolenic …
[HTML][HTML] The omega-3 polyunsaturated fatty acid docosahexaenoic acid inhibits proliferation and progression of non-small cell lung cancer cells through the reactive …
Y Yin, C Sui, F Meng, P Ma, Y Jiang - Lipids in health and disease, 2017 - Springer
Background Docosahexaenoic acid (DHA) inhibits tumor growth and progression in various
cancers, including lung cancer. However, the mechanisms involved remain unclear. The aim …
cancers, including lung cancer. However, the mechanisms involved remain unclear. The aim …
[HTML][HTML] Knockdown delta-5-desaturase in breast cancer cells that overexpress COX-2 results in inhibition of growth, migration and invasion via a dihomo-γ-linolenic …
Abstract Background Cyclooxygenase-2 (COX-2), the inducible COX form, is a bi-functional
membrane-bound enzyme that typically metabolizes arachidonic acid (downstream ω-6 fatty …
membrane-bound enzyme that typically metabolizes arachidonic acid (downstream ω-6 fatty …
[HTML][HTML] Inhibition of cancer migration and invasion by knocking down delta-5-desaturase in COX-2 overexpressed cancer cells
We recently reported that knockdown of delta-5-desaturase (a key enzyme that converts
dihomo-γ-linolenic acid, DGLA, to the downstream ω-6 arachidonic acid) promotes formation …
dihomo-γ-linolenic acid, DGLA, to the downstream ω-6 arachidonic acid) promotes formation …
Electrophilic derivatives of omega-3 fatty acids counteract lung cancer cell growth
L Siena, C Cipollina, S Di Vincenzo, M Ferraro… - Cancer Chemotherapy …, 2018 - Springer
Purpose 17-oxo-DHA is an electrophilic keto-derivative of the omega-3 fatty acid
docosahexaenoic acid (DHA) endogenously generated by cyclooxygenase-2 and a cellular …
docosahexaenoic acid (DHA) endogenously generated by cyclooxygenase-2 and a cellular …
[HTML][HTML] Dihomo-γ-linolenic acid inhibits growth of xenograft tumors in mice bearing human pancreatic cancer cells (BxPC-3) transfected with delta-5-desaturase …
We recently reported that siRNA-knockdown of delta-5-desaturase (D5D), the rate-limiting
enzyme converting upstream ω− 6 dihomo-γ-linolenic acid (DGLA) to arachidonic acid …
enzyme converting upstream ω− 6 dihomo-γ-linolenic acid (DGLA) to arachidonic acid …