Captopril (Cap) as angiotensin-converting enzyme inhibitor (ACEi) is commonly used to
treat hypertension and some types of congestive heart failure. However, few studies …

In heart failure (HF) caused by hypertension, the myocyte size increases, and the cardiac
wall thickens. A low-molecular-weight compound called ICG001 impedes β-catenin …

Aim: Inflammation and fibrosis have been shown to be critical factors in heart failure (HF)
progression. Calycosin (Cal) is the major active component of Astragalus mongholicus …

Abstract Ca2+/calmodulin-dependent protein kinase II (CaMKII) and nuclear factor-kappa B
(NF-κB) play crucial roles in pathogenesis of doxorubicin (DOX)-induced cardiomyopathy …

Since inhibiting cardiac remodeling is a critical treatment goal after myocardial infarction
(MI), many drugs have been evaluated for this purpose. Acacetin is a flavonoid compound …

Diabetic cardiomyopathy is mediated by multiple molecular mechanisms including
endoplasmic reticulum (ER) stress. Curcumin, a phenolic compound, has cytoprotective …

Background/Aims: Intracellular calcium concentration ([Ca 2+] i) homeostasis, an initial
factor of cardiac hypertrophy, is regulated by the calcium-sensing receptor (CaSR) and is …

Abstract Persistent cardiac Ca2+/calmodulin‐dependent Kinase II (CaMKII) activation was
considered to promote heart failure (HF) development, some studies believed that CaMKII …

Cardiac remodeling is the final stage of almost all cardiovascular diseases, leading to heart
failure and arrhythmias. However, the pathogenesis of cardiac remodeling is not fully …

Curcumin, isolated from rhizome of turmeric, has been widely studied as a potential
therapeutic drug for cancer. However, protective effects of curcumin on chronic heart failure …