Therapeutic potential of nociceptin/orphanin FQ peptide (NOP) receptor modulators for treatment of traumatic brain injury, traumatic stress, and their co-morbidities
ON Al Yacoub, HO Awwad, Y Zhang… - Pharmacology & …, 2022 - Elsevier
The nociceptin/orphanin FQ (N/OFQ) peptide (NOP) receptor is a member of the opioid
receptor superfamily with N/OFQ as its endogenous agonist. Wide expression of the NOP …
receptor superfamily with N/OFQ as its endogenous agonist. Wide expression of the NOP …
Recovery from traumatic brain injury is nociceptin/orphanin FQ peptide receptor genotype-, sex-, and injury severity-dependent
ON Al Yacoub, HO Awwad, KM Standifer - Journal of pharmacology and …, 2024 - ASPET
Traumatic brain injury (TBI) is a leading cause of death and disability in the United States,
and survivors often experience mental and physical health consequences that reduce …
and survivors often experience mental and physical health consequences that reduce …
Detailed in vitro pharmacological characterization of the clinically viable nociceptin/orphanin FQ peptide receptor antagonist BTRX-246040
The peptide nociceptin/orphanin FQ (N/OFQ) is the natural ligand of the N/OFQ receptor
(NOP), which is widely expressed in the central and peripheral nervous system. Selective …
(NOP), which is widely expressed in the central and peripheral nervous system. Selective …
Nociceptin/orphanin FQ peptide receptors: pharmacology and clinical implications
LC Chiou, YY Liao, PC Fan, PH Kuo… - Current drug …, 2007 - ingentaconnect.com
The advance of functional genomics revealed the superfamily of G-protein coupled
receptors (GPCRs). Hundreds of GPCRs have been cloned but many of them are orphan …
receptors (GPCRs). Hundreds of GPCRs have been cloned but many of them are orphan …
UFP‐101, a peptide antagonist selective for the nociceptin/orphanin FQ receptor
G Calo, R Guerrini, A Rizzi, S Salvadori… - CNS drug …, 2005 - Wiley Online Library
Nociceptin/orphanin FQ modulates various biological functions at central and peripheral
levels by selectively activating a G‐protein coupled receptor named N/OFQ peptide (NOP) …
levels by selectively activating a G‐protein coupled receptor named N/OFQ peptide (NOP) …
Sex differences in nociceptin/orphanin FQ peptide receptor-mediated pain and anxiety symptoms in a preclinical model of post-traumatic stress disorder
Y Zhang, I Schalo, C Durand, KM Standifer - Frontiers in psychiatry, 2019 - frontiersin.org
Nociceptin/Orphanin FQ (N/OFQ) is a neuropeptide that modulates pain transmission,
learning/memory, stress, anxiety, and fear responses via activation of the N/OFQ peptide …
learning/memory, stress, anxiety, and fear responses via activation of the N/OFQ peptide …
Nociceptin/orphanin FQ receptor antagonists as innovative antidepressant drugs
EC Gavioli - Pharmacology & therapeutics, 2013 - Elsevier
Abstract Nociceptin/orphanin FQ (N/OFQ) and its receptor (NOP) were identified in the mid
90s as a novel peptidergic system structurally related to opioids. A growing body of …
90s as a novel peptidergic system structurally related to opioids. A growing body of …
In vitro functional characterization of novel nociceptin/orphanin FQ receptor agonists in recombinant and native preparations
F Ferrari, MC Cerlesi, D Malfacini, L Asth… - European journal of …, 2016 - Elsevier
Abstract Nociceptin/Orphanin FQ (N/OFQ) regulates several biological functions via
selective activation of the N/OFQ receptor (NOP). In this study novel nonpeptide NOP …
selective activation of the N/OFQ receptor (NOP). In this study novel nonpeptide NOP …
Discovery of a Novel Series of Orally Active Nociceptin/Orphanin FQ (NOP) Receptor Antagonists Based on a Dihydrospiro(piperidine-4,7′-thieno[2,3-c]pyran) …
MA Toledo, C Pedregal, C Lafuente… - Journal of medicinal …, 2014 - ACS Publications
Nociceptin/OFQ (N/OFQ) is a 17 amino acid peptide that is the endogenous ligand for the
ORL1/NOP receptor. Nociceptin appears to regulate a host of physiological functions such …
ORL1/NOP receptor. Nociceptin appears to regulate a host of physiological functions such …
UFP‐112 a potent and long‐lasting agonist selective for the nociceptin/orphanin FQ receptor
Nociceptin/orphanin FQ (N/OFQ) controls several biological functions via selective activation
of the N/OFQ peptide receptor (NOP).[(pF) Phe4Aib7Arg14Lys15] N/OFQ‐NH2 (UFP‐112) is …
of the N/OFQ peptide receptor (NOP).[(pF) Phe4Aib7Arg14Lys15] N/OFQ‐NH2 (UFP‐112) is …