Antioxidative and angiogenesis-promoting effects of tetrahedral framework nucleic acids in diabetic wound healing with activation of the Akt/Nrf2/HO-1 pathway

S Lin, Q Zhang, S Li, T Zhang, L Wang… - … applied materials & …, 2020 - ACS Publications
Currently available strategies show limited effects in preventing morbidity and disability from
chronic diabetic wounds. Ideal vascularization is indispensable for better restoration and …

Tetrahedral framework nucleic acids promote diabetic wound healing via the Wnt signalling pathway

Z Wang, H Lu, T Tang, L Liu, B Pan, J Chen… - Cell …, 2022 - Wiley Online Library
Objectives To determine the therapeutic effect of tetrahedral framework nucleic acids
(tFNAs) on diabetic wound healing and the underlying mechanism. Materials and Methods …

Tetrahedral framework nucleic acids‐based delivery promotes intracellular transfer of healing peptides and accelerates diabetic would healing

S Lin, Q Zhang, S Li, X Qin, X Cai, H Wang - Cell Proliferation, 2022 - Wiley Online Library
Objectives Peptide‐based therapeutics are natural candidates to desirable wound healing.
However, enzymatic surroundings largely limit its stability and bioavailability. Here, we …

Tetrahedral framework nucleic acids promote scarless healing of cutaneous wounds via the AKT-signaling pathway

J Zhu, M Zhang, Y Gao, X Qin, T Zhang, W Cui… - Signal transduction and …, 2020 - nature.com
While the skin is considered the first line of defense in the human body, there are some
vulnerabilities that render it susceptible to certain threats, which is an issue that is …

Tetrahedral framework nucleic acids prevent retina ischemia-reperfusion injury from oxidative stress via activating the Akt/Nrf2 pathway

X Qin, N Li, M Zhang, S Lin, J Zhu, D Xiao, W Cui… - Nanoscale, 2019 - pubs.rsc.org
Retinal ischemia-reperfusion (I/R) injuries are involved in the universal pathological
processes of many ophthalmic diseases, including glaucoma, diabetic retinopathy, and …

Tetrahedral Framework Nucleic Acids Ameliorate Insulin Resistance in Type 2 Diabetes Mellitus via the PI3K/Akt Pathway

Y Li, Y Tang, S Shi, S Gao, Y Wang… - … Applied Materials & …, 2021 - ACS Publications
Insulin resistance (IR) is one of the essential conditions in the development of type 2
diabetes mellitus (T2DM). IR occurs in hepatic cells when the insulin receptor substrate-1 …

Tetrahedral framework nucleic acids inhibit skin fibrosis via the pyroptosis pathway

Y Jiang, S Li, T Zhang, M Zhang, YL Chen… - … Applied Materials & …, 2022 - ACS Publications
The skin is the first line of defense for the human body and is vulnerable to injury. Various
topical or systemic diseases facilitate skin inflammation, and when the intensity or duration …

Tetrahedral framework nucleic acid inhibits chondrocyte apoptosis and oxidative stress through activation of autophagy

S Shi, T Tian, Y Li, D Xiao, T Zhang… - ACS Applied Materials …, 2020 - ACS Publications
Osteoarthritis (OA) is a degenerative articular cartilage pathogenic process that is
accompanied by excessive chondrocyte apoptosis. The occurrence of chondrocyte death …

Upregulating Hif‐1α by hydrogel nanofibrous scaffolds for rapidly recruiting angiogenesis relative cells in diabetic wound

H Chen, P Jia, H Kang, H Zhang, Y Liu… - Advanced …, 2016 - Wiley Online Library
Nonhealing chronic wounds on foot are one of the most dreaded complications of diabetes,
and biomedical scaffolds remain an attractive option for repairing or regenerating tissues …

[HTML][HTML] The protective effect of tetrahedral framework nucleic acids on periodontium under inflammatory conditions

MI Zhou, S Gao, X Zhang, T Zhang, T Zhang, T Tian… - Bioactive materials, 2021 - Elsevier
Periodontitis is a common disease that causes periodontium defects and tooth loss.
Controlling inflammation and tissue regeneration are two key strategies in the treatment of …