Statins: a viable candidate for host-directed therapy against infectious diseases
Statins were first identified over 40 years ago as lipid-lowering drugs and have been
remarkably effective in treating cardiovascular diseases. As research advanced, the …
remarkably effective in treating cardiovascular diseases. As research advanced, the …
Is there potential for repurposing statins as novel antimicrobials?
E Hennessy, C Adams, FJ Reen… - Antimicrobial agents and …, 2016 - Am Soc Microbiol
Statins are members of a class of pharmaceutical widely used to reduce high levels of serum
cholesterol. In addition, statins have so-called “pleiotropic effects,” which include …
cholesterol. In addition, statins have so-called “pleiotropic effects,” which include …
Antiviral effects of statins
Introducing statins as possible widely-available drugs for the treatment of viral infections
requires an in depth review of their antiviral properties. Despite some inconsistency, a large …
requires an in depth review of their antiviral properties. Despite some inconsistency, a large …
Antifungal effects of statins
Fungal infections are estimated to be responsible for 1.5 million deaths annually. Global anti-
microbial resistance is also observed for fungal pathogens, and scientists are looking for …
microbial resistance is also observed for fungal pathogens, and scientists are looking for …
Antimicrobial and immunomodulatory attributes of statins: relevance in solid-organ transplant recipients
HY Sun, N Singh - Clinical infectious diseases, 2009 - academic.oup.com
Statins are increasingly being used to treat solid-organ transplant recipients for
posttransplantation metabolic complications. In addition to improving dyslipidemia, statins …
posttransplantation metabolic complications. In addition to improving dyslipidemia, statins …
[PDF][PDF] Statins enhance formation of phagocyte extracellular traps
OA Chow, M von Köckritz-Blickwede, AT Bright… - Cell host & …, 2010 - cell.com
Statins are inhibitors of 3-hydroxy 3-methylglutaryl coenzyme A (HMG-CoA) reductase, the
rate-limiting enzyme in cholesterol biosynthesis. Recent clinico-epidemiologic studies …
rate-limiting enzyme in cholesterol biosynthesis. Recent clinico-epidemiologic studies …
In vitro antibacterial effects of statins against bacterial pathogens causing skin infections
With financial considerations impeding research and development of new antibiotics, drug
repurposing (finding new indications for old drugs) emerges as a feasible alternative. Statins …
repurposing (finding new indications for old drugs) emerges as a feasible alternative. Statins …
Statins could be used to control replication of some viruses, including HIV-1
C Gilbert, M Bergeron, S Méthot, JF Giguère… - Viral …, 2005 - liebertpub.com
Statins are mainly known for their plasma cholesterol-lowering properties and are widely
used for the prevention of cardiovascular diseases. They however also exert pleiotropic …
used for the prevention of cardiovascular diseases. They however also exert pleiotropic …
[HTML][HTML] Statins: antimicrobial resistance breakers or makers?
Methods A literature search using keywords “statin” or “statins” combined with “minimum
inhibitory concentration”(MIC) was performed in six databases on 7th April 2017. After …
inhibitory concentration”(MIC) was performed in six databases on 7th April 2017. After …
Statins for infection and sepsis: a systematic review of the clinical evidence
ME Falagas, GC Makris, DK Matthaiou… - Journal of …, 2008 - academic.oup.com
Introduction Statins are currently used for hyperlipidaemia control and considered useful for
protection from cardiovascular events. In addition, there is increasing evidence for the …
protection from cardiovascular events. In addition, there is increasing evidence for the …