Statins: a viable candidate for host-directed therapy against infectious diseases

SP Parihar, R Guler, F Brombacher - Nature Reviews Immunology, 2019 - nature.com
Statins were first identified over 40 years ago as lipid-lowering drugs and have been
remarkably effective in treating cardiovascular diseases. As research advanced, the …

Is there potential for repurposing statins as novel antimicrobials?

E Hennessy, C Adams, FJ Reen… - Antimicrobial agents and …, 2016 - Am Soc Microbiol
Statins are members of a class of pharmaceutical widely used to reduce high levels of serum
cholesterol. In addition, statins have so-called “pleiotropic effects,” which include …

Antiviral effects of statins

AM Gorabi, N Kiaie, V Bianconi, T Jamialahmadi… - Progress in Lipid …, 2020 - Elsevier
Introducing statins as possible widely-available drugs for the treatment of viral infections
requires an in depth review of their antiviral properties. Despite some inconsistency, a large …

Antifungal effects of statins

A Tavakkoli, TP Johnston, A Sahebkar - Pharmacology & therapeutics, 2020 - Elsevier
Fungal infections are estimated to be responsible for 1.5 million deaths annually. Global anti-
microbial resistance is also observed for fungal pathogens, and scientists are looking for …

Antimicrobial and immunomodulatory attributes of statins: relevance in solid-organ transplant recipients

HY Sun, N Singh - Clinical infectious diseases, 2009 - academic.oup.com
Statins are increasingly being used to treat solid-organ transplant recipients for
posttransplantation metabolic complications. In addition to improving dyslipidemia, statins …

[PDF][PDF] Statins enhance formation of phagocyte extracellular traps

OA Chow, M von Köckritz-Blickwede, AT Bright… - Cell host & …, 2010 - cell.com
Statins are inhibitors of 3-hydroxy 3-methylglutaryl coenzyme A (HMG-CoA) reductase, the
rate-limiting enzyme in cholesterol biosynthesis. Recent clinico-epidemiologic studies …

In vitro antibacterial effects of statins against bacterial pathogens causing skin infections

HHT Ko, RR Lareu, BR Dix, JD Hughes - European Journal of Clinical …, 2018 - Springer
With financial considerations impeding research and development of new antibiotics, drug
repurposing (finding new indications for old drugs) emerges as a feasible alternative. Statins …

Statins could be used to control replication of some viruses, including HIV-1

C Gilbert, M Bergeron, S Méthot, JF Giguère… - Viral …, 2005 - liebertpub.com
Statins are mainly known for their plasma cholesterol-lowering properties and are widely
used for the prevention of cardiovascular diseases. They however also exert pleiotropic …

[HTML][HTML] Statins: antimicrobial resistance breakers or makers?

HHT Ko, RR Lareu, BR Dix, JD Hughes - PeerJ, 2017 - peerj.com
Methods A literature search using keywords “statin” or “statins” combined with “minimum
inhibitory concentration”(MIC) was performed in six databases on 7th April 2017. After …

Statins for infection and sepsis: a systematic review of the clinical evidence

ME Falagas, GC Makris, DK Matthaiou… - Journal of …, 2008 - academic.oup.com
Introduction Statins are currently used for hyperlipidaemia control and considered useful for
protection from cardiovascular events. In addition, there is increasing evidence for the …