Rationale and objectives Although onset of drug use during adolescence appears to
increase long-term vulnerability to drug dependence in humans, relatively little is known …

Rationale Adult cocaine addicts, abstinent at the time of testing, show a variety of
neurocognitive impairments. Less clear is whether there are differences in the degree of …

Abstracts Rationale Extinction responding and cue-induced reinstatement of cocaine
seeking after 60-days of forced abstinence are attenuated in male rats that self-administered …

Rationale In human and animal studies, adolescence marks a period of increased
vulnerability to the initiation and subsequent abuse of drugs. Adolescents may be especially …

Adolescent rats take cocaine more readily than adults, are more sensitive to lower doses of
the drug and work harder for it. It remains unknown if adolescent‐onset of cocaine use has …

Rationale Early-onset drug taking is associated with increased likelihood of addiction, but it
is unclear whether early onset is causal in development of addiction. Many other factors are …

Rationale Previously, we demonstrated that neonatal isolation increases acquisition of
cocaine self-administration in adult male rats. Objective Now we examine whether neonatal …

Rationale Most lifelong drug addiction in humans originates during adolescence. Important
structural and functional changes in the brain occur during adolescence, but there has been …

Rationale Adolescence is a critical period for drug addiction. Acute stimulant exposure elicits
different behavioral responses in adolescent and adult rodents. The same biological …

Relapse to drug use is often precipitated by exposure to drug associated cues that evoke
craving. Cue-induced drug craving has been observed in both animals and humans to …