The number of colorectal cancer (CRC) patients is increasing worldwide. Accumulating
evidence has shown that the tumor microenvironment (TME), including macrophages …

The importance of the prostaglandin (PG) synthesis pathway, particularly the rate-limiting
enzymatic step catalyzed by cyclooxygenase, to colorectal carcinogenesis and development …

Inflammation in the colon contributes significantly to colorectal cancer development. While
aspirin reduces the colorectal cancer risk, its action mechanism, especially in inflammation …

Although colon cancer is one of the most important triggers of cancer related mortality, a few
therapeutic options exist for this disease, including combination chemotherapy, anti-EGFR …

Abstract Prostaglandin E 2 (PGE 2) is a bioactive lipid that elicits a wide range of biological
effects associated with inflammation and cancer. PGE 2 exerts diverse effects on cell …

It is widely accepted that alterations to cyclooxygenase-2 (COX-2) expression and the
abundance of its enzymatic product prostaglandin E 2 (PGE 2) have key roles in influencing …

Cyclooxygenase (COX)-generated prostaglandin E 2 (PGE 2) plays critical roles in
colorectal carcinogenesis. Recently, we have shown that PGE 2 and transforming growth …

Accumulating evidence indicates that overproduction of prostanoids attributable to
overexpression of cyclooxygenase-2 (COX-2) plays an important role in colon …

Simple Summary Inflammation is assessed as a hallmark of cancer and it is now widely
recognized that there exists a direct causal link between inflammation and tumors. Among …

Colorectal cancer is a major cause of mortality and whilst up to 80% of sporadic colorectal
tumours are considered preventable, trends toward increasing obesity suggest the potential …