Lung function declines with advancing age. To improve our understanding of the structure-
function relationships leading to this decline, we investigated structural alterations in the …

In the current study, we hypothesize that senescent-dependent changes between airway
and lung parenchymal tissues of C57BL/6J (B6) mice are not synchronized with respect to …

This study investigated the morphological changes of lungs in F344/N rats (9–36 months
old). We initially examined general and quantitative morphological changes, and then we …

Previous work investigating respiratory system mechanics in mice has reported an aging-
related increase in compliance and mean linear intercept (L m). However, these changes …

Previous studies from our laboratories showed lung development differences between
inbred strains of mice. In the present study, the C57BL/6J (B6) and DBA/2J (D2) strains were …

The progressive decline of lung function with aging is associated with changes in lung
structure at all levels, from conducting airways to acinar airways (alveolar ducts and sacs) …

This study identified gene expression profiles that provided evidence for genomic
mechanisms underlying the pathophysiology of aging lung. Aging lungs from C57BL/6 (B6) …

Morbidity and mortality rates in acute lung injury (ALI) increase with age. As alveolar
epithelial type II cells (AE2) are crucial for lung function and repair, we hypothesized that …

Lung aging is associated with structural remodeling, a decline of respiratory function and a
higher susceptibility to acute and chronic lung diseases. Individual factors that modulate …

Postnatal lung maturation generates a large number of small alveoli, with concomitant
thinning of alveolar septal walls, generating a large gas exchange surface area but …