Osteoarthritis (OA) is the most common degenerative joint disease. In 1999, two members of
the A Disintegrin and Metalloproteinase with Thrombospondin Motifs (ADAMTS) family of …

Degenerative diseases are still a challenging issue in clinical therapy; even though in
several cases it is possible to treat symptoms, drugs able to block disease progression are …

In healthy cartilage, effective weight-bearing requires a high concentration of intact
aggrecan. Degradation and loss of aggrecan are features of osteoarthritis (OA). It is unclear …

Over the last decade, there has been a large effort to target aggrecanases, which are
responsible for the degradation of the aggrecan in the extracellular matrix of joints, in order …

Adamalysin-like metalloproteinases with thrombospondin (TS) motifs (ADAMTS)-5 is the
multi-domain metalloproteinase that most potently degrades aggrecan proteoglycan in the …

Purpose: Increased aggrecanase activity is a well-known trigger factor for osteoarthritis (OA),
initiating loss of cartilage aggrecan that precedes more severe cartilage degradation. A …

A disintegrin and metalloproteinase with thrombospondin motifs-4 (ADAMTS-4) and
ADAMTS-5 are zinc metalloproteases commonly referred to as aggrecanase-1 and …

Importance of the field: Aggrecanases are members of a disintegrin and metalloprotease
with thrombospondin motif family of zinc metalloproteases involved in the cleavage of …

From the time of their discovery in 1999, the aggrecanases, and ADAMTS-5 in particular,
have been heavily investigated as targets for disease-modifying osteoarthritis drug …

Loss of aggrecan from articular cartilage is an early and critical event in the pathogenesis of
osteoarthritis (OA) and is enzymatically mediated by aggrecanase activity. Since the …