Formaldehyde exposure and leukemia risk: a comprehensive review and network-based toxicogenomic approach

DS Kang, HS Kim, JH Jung, CM Lee, YS Ahn… - Genes and …, 2021 - Springer
Formaldehyde is a widely used but highly reactive and toxic chemical. The International
Agency for Research on Cancer classifies formaldehyde as a Group 1 carcinogen, based on …

Formaldehyde and leukemia: epidemiology, potential mechanisms, and implications for risk assessment

L Zhang, LEB Freeman, J Nakamura… - Environmental and …, 2010 - Wiley Online Library
Formaldehyde is widely used in the United States and other countries. Occupational and
environmental exposures to formaldehyde may be associated with an increased risk of …

Formaldehyde exposure and leukemia: a new meta-analysis and potential mechanisms

L Zhang, C Steinmaus, DA Eastmond, XK Xin… - … Research/Reviews in …, 2009 - Elsevier
Formaldehyde is an economically important chemical, to which more than 2 million US
workers are occupationally exposed. Substantially more people are exposed to …

Network-based integrated analysis for toxic effects of high-concentration formaldehyde inhalation exposure through the toxicogenomic approach

DS Kang, N Lee, DY Shin, YJ Jang, SH Lee, KM Lim… - Scientific Reports, 2022 - nature.com
Formaldehyde is a colorless, pungent, highly reactive, and toxic environmental pollutant
used in various industries and products. Inhaled formaldehyde is a human and animal …

Formaldehyde and brain disorders: a meta-analysis and bioinformatics approach

I Rana, L Rieswijk, C Steinmaus, L Zhang - Neurotoxicity research, 2021 - Springer
While there is significant investigation and investment in brain and neurodegenerative
disease research, current understanding of the etiologies of illnesses like Alzheimer's …

Critical review and synthesis of the epidemiologic evidence on formaldehyde exposure and risk of leukemia and other lymphohematopoietic malignancies

H Checkoway, P Boffetta, DJ Mundt, KA Mundt - Cancer Causes & Control, 2012 - Springer
Purpose Recent epidemiologic studies indicate elevated risks for some
lymphohematopoietic malignancies (LHM) related to formaldehyde exposure. We performed …

Bone marrow injury induced via oxidative stress in mice by inhalation exposure to formaldehyde

Y Zhang, X Liu, C McHale, R Li, L Zhang, Y Wu, X Ye… - PloS one, 2013 - journals.plos.org
Objective Formaldehyde, a ubiquitous environmental pollutant has been classified as a
human leukemogen. However, toxicity of formaldehyde in bone marrow, the target site of …

Is exposure to formaldehyde in air causally associated with leukemia?—A hypothesis-based weight-of-evidence analysis

LR Rhomberg, LA Bailey, JE Goodman… - Critical Reviews in …, 2011 - Taylor & Francis
Recent scientific debate has focused on the potential for inhaled formaldehyde to cause
lymphohematopoietic cancers, particularly leukemias, in humans. The concern stems from …

Occupational exposure to formaldehyde, hematotoxicity, and leukemia-specific chromosome changes in cultured myeloid progenitor cells

L Zhang, X Tang, N Rothman, R Vermeulen, Z Ji… - … Biomarkers & Prevention, 2010 - AACR
There are concerns about the health effects of formaldehyde exposure, including
carcinogenicity, in light of elevated indoor air levels in new homes and occupational …

Formaldehyde metabolism and its impact on human health

H Reingruber, LB Pontel - Current opinion in toxicology, 2018 - Elsevier
Human health is threatened by exposure to reactive toxins that can damage fundamental
biomolecules such as DNA and proteins. One of these molecules is formaldehyde, the …