Background Metabolic dysfunction and dysregulation of leptin signaling have been linked to
Alzheimer's disease (AD)'s pathophysiology. The objectives of this study were to examine …

Background: animal studies suggest a neuroprotective role for leptin, but human studies
have shown mixed results. We examined whether plasma leptin levels in individuals with …

Background: Low plasma leptin levels can be a risk factor for Alzheimer's disease (AD) but
the relation of leptin with disease progression in clinical AD is unknown. Objective: The aim …

Alzheimer's disease (AD) is the most common cause of progressive dementia in the elderly
population. AD is histologically characterized by accumulation of amyloid-β protein (Aβ) on …

Analysis of data derived from the Alzheimer's Disease Neuroimaging Initiative (ADNI)
program showed plasma leptin levels in individuals with Mild Cognitive Impairment (MCI) or …

Context The adipokine leptin facilitates long-term potentiation and synaptic plasticity in the
hippocampus, promotes β-amyloid clearance, and improves memory function in animal …

Leptin is a peptide hormone secreted by adipocytes. It has been shown to modulate
production and clearance of amyloid beta (Aβ) in rodent models. We sought to determine if …

Background: There is growing interest in the pathophysiological processes of preclinical
Alzheimer's disease (AD), including the potential role of leptin. Human studies have shown …

Background: US studies suggest that leptin, a fat-derived hormone, may be protective
against the development of dementia. Objective: To investigate the complex relationship …

Leptin, an adipocytokine produced in the peripheral system as well as in the brain, is
implicated in obesity, food intake, glucose homeostasis, and energy expenditure. Leptin …