Background Studies showed that upregulation of Nav1. 6 increased the neuronal excitability
and participated in neuropathic pain in the dorsal root ganglion (DRG). However, the …

Postoperative pain remains a complex problem that is difficult to manage in the clinical
context, seriously affecting rehabilitation and the quality of life of patients after surgery …

Activation of nucleus factor-kappaB (NF-κB) in the dorsal root ganglia (DRG) is critical for
development of neuropathic pain. The underlying mechanisms, however, are largely …

Background Neuropathic pain caused by peripheral nerve injury is a chronic disorder that
represents a significant clinical challenge because the pathological mechanisms have not …

Voltage-gated sodium channels (Nav) are essential for the generation and conduction of
action potentials. Peripheral inflammation increases the expression of Nav1. 7 and Nav1. 8 …

The mechanisms underlying neuropathic pain induction are very complex but might involve
abnormal spontaneous activity in the sensory dorsal root ganglion (DRG). Voltage‐gated …

Pulpitis causes significant changes in the peripheral nervous system, which induce
hyperalgesia. However, the relationship between neuronal activity and Nav1. 7 expression …

Voltage-gated sodium channels NaV1. 7, NaV1. 8 and NaV1. 9 have been the focus for pain
studies because their mutations are associated with human pain disorders, but the role of …

Although the mouse model of incisional pain is broadly used, the mechanisms underlying
plantar incision-induced nociception are not fully understood. This work investigates the role …

Diabetic neuropathy (DN) is a common form of peripheral neuropathy, yet the mechanisms
responsible for chronic pain in this disease are poorly understood. The up-regulation of the …