The acquisition of drug, including alcohol, use is associated with activation of the
mesolimbic dopamine system. However, over the course of drug exposure the control over …

Excessive drinking is an important behavioural characteristic of alcohol addiction, but not the
only one. Individuals addicted to alcohol crave alcoholic beverages, spend time seeking …

Chronic alcohol self-administration leads to alcohol-seeking behavior that is habitual and
insensitive to changes in the value of the earned alcohol. Such behavior has been shown to …

BACKGROUND: Addictions are defined by a loss of flexible control over behavior. The
development of response habits might reflect early changes in behavioral control. The …

The development of alcoholism may involve a shift from goal‐directed to habitual drinking.
These action control systems are distinct in the dorsal striatum, with the dorsomedial striatum …

Loss of flexible control over alcohol use may contribute to the development of alcohol use
disorders. An increased contribution of response habits to alcohol‐related behaviors may …

Humans greatly differ in how they cope with stress, a natural behavior learnt through
negative reinforcement. Some individuals engage in displacement activities, others in …

The dorsal striatum (DS) is implicated in behavioral and neural processes including action
control and reinforcement. Alcohol alters these processes in rodents, and it is believed that …

A decade ago, we hypothesized that drug addiction can be viewed as a transition from
voluntary, recreational drug use to compulsive drug-seeking habits, neurally underpinned by …

Neuroadaptations following chronic exposure to alcohol are hypothesized to play important
roles in alcohol-induced alterations in behavior, in particular increased alcohol drinking and …