T‐cell immunoglobulin mucin 3 blockade drives an antitumor immune response in head and neck cancer

JF Liu, SR Ma, L Mao, LL Bu, GT Yu, YC Li… - Molecular …, 2017 - Wiley Online Library
T‐cell immunoglobulin mucin 3 (TIM 3) contributes to immune suppression during
progression of many cancers, but the precise role of TIM 3 in head and neck squamous cell …

Blockade of TIM3 relieves immunosuppression through reducing regulatory T cells in head and neck cancer

JF Liu, L Wu, LL Yang, WW Deng, L Mao, H Wu… - Journal of Experimental …, 2018 - Springer
Background T-cell immunoglobulin mucin 3 (TIM3) is a negative immune checkpoint and
plays a crucial part in tumor-induced immune suppression. However, the mechanism of …

Tim-3 expression in cervical cancer promotes tumor metastasis

Y Cao, X Zhou, X Huang, Q Li, L Gao, L Jiang… - PloS one, 2013 - journals.plos.org
Background T cell immunoglobulin mucin-3 (Tim-3) has been identified as a negative
regulator of anti-tumor immunity. Recent studies highlight the important role of Tim-3 in the …

Upregulation of T-cell immunoglobulin and mucin-domain containing-3 (Tim-3) in monocytes/macrophages associates with gastric cancer progression

Z Wang, N Yin, Z Zhang, Y Zhang… - Immunological …, 2017 - Taylor & Francis
ABSTRACT T-cell immunoglobulin and mucin-domain containing-3 (Tim-3) is an important
immune regulatory molecule in cancer immune system. However, expression and function of …

TIM-3 participates in the invasion and metastasis of nasopharyngeal carcinoma via SMAD7/SMAD2/SNAIL1 axis-mediated epithelial-mesenchymal transition

Y Xiao, J Qing, B Li, L Chen, S Nong… - OncoTargets and …, 2020 - Taylor & Francis
Background T-cell immunoglobulin and mucin domain-containing molecule-3 (TIM-3) was
originally found to negatively regulate immune response and mediate immune escape in …

Tim-3 mediates T cell trogocytosis to limit antitumor immunity

O Pagliano, RM Morrison, JM Chauvin… - The Journal of …, 2022 - Am Soc Clin Investig
T cell immunoglobulin mucin domain-containing protein 3 (Tim-3) negatively regulates
innate and adaptive immunity in cancer. To identify the mechanisms of Tim-3 in cancer …

T‐cell immunoglobulin mucin‐3 expression in bladder urothelial carcinoma: clinicopathologic correlations and association with survival

M Yang, Q Yu, J Liu, W Fu, Y Cao, L Yu… - Journal of surgical …, 2015 - Wiley Online Library
Background T cell immunoglobulin mucin‐3 (Tim‐3) was initially recognized as a pivotal
immune checkpoint inhibitor that maintains immune homeostasis and tolerance. Recently …

Significance of TIM-3 expression by CD4+ and CD8+ T lymphocytes in tumor-draining lymph nodes from patients with breast cancer

S Shariati, A Ghods, M Zohouri, R Rasolmali… - Molecular …, 2020 - Elsevier
T cell immunoglobulin and mucin domain-containing protein 3 (TIM-3), which is expressed
by immune and nonimmune cells, has been shown to play immunoregulatory roles in the …

TIM-3 promotes the metastasis of esophageal squamous cell carcinoma by targeting epithelial-mesenchymal transition via the Akt/GSK-3β/Snail signaling pathway

B Shan, H Man, J Liu, L Wang, T Zhu… - Oncology …, 2016 - spandidos-publications.com
T-cell immunoglobulin and mucin domain-containing protein-3 (TIM-3), a negative regulator
of antitumor immune response, has been demonstrated to be involved in the onset and …

[HTML][HTML] Expression of Tim-3 in breast cancer tissue promotes tumor progression

S Cheng, F Han, Y Xu, T Qu, Y Ju - International Journal of Clinical …, 2018 - ncbi.nlm.nih.gov
Abstract T-cell immunoglobulin mucin-3 (Tim-3) plays a pivotal role in immune regulation
and tolerance induction as a negative regulatory molecule on innate versus adaptive …