Pathogenic mechanisms of T cells in several central nervous system (CNS) disorders are
well-established. However, more recent studies have uncovered compelling beneficial roles …

T cells within the central nervous system (CNS) have been generally considered
pathogenic, especially in the context of neuroinflammatory disease. However, recent …

CD4+ T cells orchestrate innate and adaptive immunity. In the central nervous system they
modulate immune responses including cell trafficking and glial neuroregulatory functions …

The interaction between peripheral immune cells and the brain is an important component of
the neuroimmune axis. Unconventional T cells, which include natural killer T (NKT) cells …

The interaction between the peripheral immune system and the brain is increasingly being
recognized as an important layer of neuroimmune regulation and plays vital roles in brain …

Inflammation is a biological process that dynamically alters the surrounding
microenvironment, including participating immune cells. As a well‐protected organ …

Central nervous system (CNS) inflammation occurs in a large number of neurological
diseases. The type and magnitude of CNS inflammation, as well as the T‐cell contribution …

Neuroinflammation is involved in several neurodegenerative disorders and emerging
evidence indicates that it constitutes a critical process that is required for the progression of …

T cells play a central role in homeostasis and host defense against infectious diseases. T
cell dysregulation can lead to recognizing self-antigens as foreign antigens, causing a …

The healthy immune system has natural checkpoints that temper pernicious inflammation.
Cells mediating these checkpoints include regulatory T cells, regulatory B cells, regulatory …