Gene expression signatures identify novel therapeutics for metastatic pancreatic neuroendocrine tumors

AT Scott, M Weitz, PJ Breheny, PH Ear, B Darbro… - Clinical cancer …, 2020 - AACR
Purpose: Pancreatic neuroendocrine tumors (pNETs) are uncommon malignancies noted for
their propensity to metastasize and comparatively favorable prognosis. Although both the …

Translational diagnostics and therapeutics in pancreatic neuroendocrine tumors

JE Maxwell, SK Sherman, JR Howe - Clinical cancer research, 2016 - AACR
Pancreatic neuroendocrine tumors (PNET) are rare tumors, but have been increasing in
incidence. Although typically thought of as indolent, more than half of patients present with …

Molecular characterization of metastatic pancreatic neuroendocrine tumors (PNETs) using whole-genome and transcriptome sequencing

H Wong, KC Yang, Y Shen… - Molecular …, 2018 - molecularcasestudies.cshlp.org
Pancreatic neuroendocrine tumors (PNETs) are a genomically and clinically heterogeneous
group of pancreatic neoplasms often diagnosed with distant metastases. Recurrent somatic …

Real-time genomic characterization of metastatic pancreatic neuroendocrine tumors has prognostic implications and identifies potential germline actionability

N Raj, R Shah, Z Stadler, S Mukherjee, J Chou… - JCO precision …, 2018 - ascopubs.org
Purpose We assessed the usefulness of real-time molecular profiling through next-
generation sequencing (NGS) in predicting the tumor biology of advanced pancreatic …

[HTML][HTML] Pancreatic neuroendocrine tumors: molecular mechanisms and therapeutic targets

CK Maharjan, PH Ear, CG Tran, JR Howe… - Cancers, 2021 - mdpi.com
Simple Summary Pancreatic neuroendocrine tumors (pNETs) are rare, indolent cancers
whose causation is only partly understood. An increasing number of studies have uncovered …

[HTML][HTML] Insights into the biology and treatment strategies of pancreatic neuroendocrine tumors

JL Buicko, BM Finnerty, T Zhang, BJ Kim… - Annals of pancreatic …, 2019 - ncbi.nlm.nih.gov
Pancreatic neuroendocrine tumors (PNETs) are the second most common primary
pancreatic neoplasms after pancreatic ductal adenocarcinoma. PNETs present with widely …

[HTML][HTML] Molecular signatures and their clinical utility in pancreatic neuroendocrine tumors

PD Chatani, SK Agarwal, SM Sadowski - Frontiers in Endocrinology, 2021 - frontiersin.org
Pancreatic neuroendocrine tumors (PNETs) are classified based on their histologic
differentiation and proliferative indices, which have been used extensively to determine …

[HTML][HTML] Therapy for metastatic pancreatic neuroendocrine tumors

RE Rossi, S Massironi, D Conte… - Annals of translational …, 2014 - ncbi.nlm.nih.gov
Background Pancreatic neuroendocrine tumors (pNETs) are frequently malignant (50-80%,
except for insulinoma) and may show an aggressive course with metastases to the liver as …

Molecular profile of pancreatic neuroendocrine neoplasms (PanNENs): Opportunities for personalized therapies

J Arakelyan, D Zohrabyan, PA Philip - Cancer, 2021 - Wiley Online Library
Pancreatic neuroendocrine neoplasms (panNENs) are the second most common epithelial
tumors of the pancreas. Despite improvements in prognostic grading and staging systems, it …

Pancreatic neuroendocrine tumors: Challenges in an underestimated disease

A Viúdez, A De Jesus-Acosta, FL Carvalho… - Critical reviews in …, 2016 - Elsevier
Pancreatic neuroendocrine tumours (PanNETs) are considered a relatively unusual
oncologic entity. Due to its relative good prognosis, surgery remains the goal standard …