Gene expression signatures identify novel therapeutics for metastatic pancreatic neuroendocrine tumors
Purpose: Pancreatic neuroendocrine tumors (pNETs) are uncommon malignancies noted for
their propensity to metastasize and comparatively favorable prognosis. Although both the …
their propensity to metastasize and comparatively favorable prognosis. Although both the …
Translational diagnostics and therapeutics in pancreatic neuroendocrine tumors
JE Maxwell, SK Sherman, JR Howe - Clinical cancer research, 2016 - AACR
Pancreatic neuroendocrine tumors (PNET) are rare tumors, but have been increasing in
incidence. Although typically thought of as indolent, more than half of patients present with …
incidence. Although typically thought of as indolent, more than half of patients present with …
Molecular characterization of metastatic pancreatic neuroendocrine tumors (PNETs) using whole-genome and transcriptome sequencing
H Wong, KC Yang, Y Shen… - Molecular …, 2018 - molecularcasestudies.cshlp.org
Pancreatic neuroendocrine tumors (PNETs) are a genomically and clinically heterogeneous
group of pancreatic neoplasms often diagnosed with distant metastases. Recurrent somatic …
group of pancreatic neoplasms often diagnosed with distant metastases. Recurrent somatic …
Real-time genomic characterization of metastatic pancreatic neuroendocrine tumors has prognostic implications and identifies potential germline actionability
Purpose We assessed the usefulness of real-time molecular profiling through next-
generation sequencing (NGS) in predicting the tumor biology of advanced pancreatic …
generation sequencing (NGS) in predicting the tumor biology of advanced pancreatic …
[HTML][HTML] Pancreatic neuroendocrine tumors: molecular mechanisms and therapeutic targets
Simple Summary Pancreatic neuroendocrine tumors (pNETs) are rare, indolent cancers
whose causation is only partly understood. An increasing number of studies have uncovered …
whose causation is only partly understood. An increasing number of studies have uncovered …
[HTML][HTML] Insights into the biology and treatment strategies of pancreatic neuroendocrine tumors
Pancreatic neuroendocrine tumors (PNETs) are the second most common primary
pancreatic neoplasms after pancreatic ductal adenocarcinoma. PNETs present with widely …
pancreatic neoplasms after pancreatic ductal adenocarcinoma. PNETs present with widely …
[HTML][HTML] Molecular signatures and their clinical utility in pancreatic neuroendocrine tumors
PD Chatani, SK Agarwal, SM Sadowski - Frontiers in Endocrinology, 2021 - frontiersin.org
Pancreatic neuroendocrine tumors (PNETs) are classified based on their histologic
differentiation and proliferative indices, which have been used extensively to determine …
differentiation and proliferative indices, which have been used extensively to determine …
[HTML][HTML] Therapy for metastatic pancreatic neuroendocrine tumors
RE Rossi, S Massironi, D Conte… - Annals of translational …, 2014 - ncbi.nlm.nih.gov
Background Pancreatic neuroendocrine tumors (pNETs) are frequently malignant (50-80%,
except for insulinoma) and may show an aggressive course with metastases to the liver as …
except for insulinoma) and may show an aggressive course with metastases to the liver as …
Molecular profile of pancreatic neuroendocrine neoplasms (PanNENs): Opportunities for personalized therapies
J Arakelyan, D Zohrabyan, PA Philip - Cancer, 2021 - Wiley Online Library
Pancreatic neuroendocrine neoplasms (panNENs) are the second most common epithelial
tumors of the pancreas. Despite improvements in prognostic grading and staging systems, it …
tumors of the pancreas. Despite improvements in prognostic grading and staging systems, it …
Pancreatic neuroendocrine tumors: Challenges in an underestimated disease
A Viúdez, A De Jesus-Acosta, FL Carvalho… - Critical reviews in …, 2016 - Elsevier
Pancreatic neuroendocrine tumours (PanNETs) are considered a relatively unusual
oncologic entity. Due to its relative good prognosis, surgery remains the goal standard …
oncologic entity. Due to its relative good prognosis, surgery remains the goal standard …