A nationwide population-based study on the survival of patients with pancreatic neuroendocrine tumors in the Netherlands

CG Genc, HJ Klümpen, MGH Van Oijen… - World journal of …, 2018 - Springer
Background Large population-based studies give insight into the prognosis and treatment
outcomes of patients with pancreatic neuroendocrine tumors (pNETs). Therefore, we provide …

[HTML][HTML] Functional and non-functional pancreatic neuroendocrine tumours: ENETS or AJCC TNM staging system?

M Yang, NW Ke, Y Zhang, CL Tan, BL Tian, XB Liu… - Oncotarget, 2017 - ncbi.nlm.nih.gov
Background There are currently 2 Tumour-Node-Metastasis (TNM) staging systems for
pancreatic neuroendocrine tumours (p-NETs)-European Neuroendocrine Tumour Society …

Identification of potential therapeutic targets by gene-expression profiling in pancreatic endocrine tumors

A Couvelard, J Hu, G Steers, OT Dermot, A Sauvanet… - Gastroenterology, 2006 - Elsevier
Background & Aims: Prediction of biological behavior in pancreatic endocrine tumors (PET)
is difficult on histologic criteria alone. The aim of this study was to characterize PET gene …

A shining light in the darkness for the treatment of pancreatic neuroendocrine tumors

J Capdevila, J Tabernero - Cancer discovery, 2011 - AACR
Gastroenteropancreatic neuroendocrine tumors are rare neoplasms; past decades have
seen limited research channeled into this area. Recently, 2 placebo-controlled phase III …

Importance of lymph node involvement in pancreatic neuroendocrine tumors: impact on survival and implications for surgical resection

T Curran, BA Pockaj, RJ Gray, TR Halfdanarson… - Journal of …, 2015 - Elsevier
Background Conflicting data exist on predictors of nodal metastases and their impact on
survival in patients with pancreatic neuroendocrine tumors (PNETs). We aim to identify …

[HTML][HTML] Pancreatic neuroendocrine tumours: Grade is superior to T, N, or M status in predicting outcome and selecting patients for chemotherapy: A retrospective …

H Zhai, D Li, Q Feng, X Qian, L Li, J Yao - International Journal of Surgery, 2019 - Elsevier
Background Pancreatic neuroendocrine tumours (pNETs) are a rare and heterogeneous
group of tumours with an increasing incidence. Current staging criteria for pNETs remain …

An insight on functioning pancreatic neuroendocrine neoplasms

M Bevere, A Gkountakos, FM Martelli, A Scarpa… - Biomedicines, 2023 - mdpi.com
Pancreatic neuroendocrine neoplasms (PanNENs) are rare neoplasms arising from islets of
the Langerhans in the pancreas. They can be divided into two groups, based on peptide …

Resistance to targeted therapies in pancreatic neuroendocrine tumors (PNETs): molecular basis, preclinical data, and counteracting strategies

A Tijeras-Raballand, C Neuzillet, A Couvelard… - Targeted …, 2012 - Springer
Management of advanced pancreatic neuroendocrine tumors (PNETs) is challenging.
Chemotherapy has remained for decades the only validated therapeutic option, with …

[HTML][HTML] Genes involved in angiogenesis and mTOR pathways are frequently mutated in Asian patients with pancreatic neuroendocrine tumors

WC Chou, PH Lin, YC Yeh, YM Shyr… - … journal of biological …, 2016 - ncbi.nlm.nih.gov
Introduction: To address the issue of limited data on and inconsistent findings for genetic
alterations in pancreatic neuroendocrine tumors (pNETs), we analyzed sequences of known …

A patient-derived xenograft model of pancreatic neuroendocrine tumors identifies sapanisertib as a possible new treatment for everolimus-resistant tumors

CE Chamberlain, MS German, K Yang, J Wang… - Molecular cancer …, 2018 - AACR
Patients with pancreatic neuroendocrine tumors (PNET) commonly develop advanced
disease and require systemic therapy. However, treatment options remain limited, in part …