Human-derived neuronal cell lines are progressively being utilized in understanding
neurobiology and preclinical translational research as they are biologically more relevant …

Neural progenitor cells existing in the developing and adult brain retain the capacity to self
renew and to produce the major cell types of the brain opening new avenues for restorative …

Parkinson's disease (PD) is a neurodegenerative disorder, caused by a selective loss of
dopaminergic neurons in the substantia nigra. In PD, the best therapeutic modalities cannot …

The study of mechanisms that underlie Parkinson's disease (PD), as well as translational
drug development, has been hindered by the lack of appropriate models. Both cell culture …

Parkinson's disease (PD) is the second most common neurodegenerative disorder and has
both unknown etiology and non-curative therapeutic options. Patients begin to present the …

Dopaminergic neurons represent less than 1% of the total number of neurons in the brain.
This low amount of neurons regulates important brain functions such as motor control …

Properly committed neural stem cells constitute a promising source of cells for
transplantation in Parkinson's disease, but a protocol for controlled dopaminergic …

Using Parkinson's disease as a prototype of neurodegenerative diseases, we propose
applications of human stem cells in the development of therapeutics for neurodegenerative …

Cell replacement therapies are an attractive mode of treatment for neurodegenerative
disorders as they have the potential to alleviate or modify disease symptoms and restore …

Ectopic expression of lineage-specific transcription factors facilitates the conversion of
mammalian somatic cells into dopaminergic (DA) neurons, which is a promising strategy for …