“Regenerative medicine” may hopefully provide some relief or therapy for diseases which
we can currently not or only barely treat. This is also true for most diseases presenting with …

In Parkinson's disease (PD), substantia nigra (SN) dopaminergic (DA) neurons degenerate,
while related ventral tegmental area (VTA) DA neurons remain relatively unaffected. Here …

Autologous neural stem cells (NSCs) may offer a promising source for deriving
dopaminergic (DA) cells for treatment of Parkinson's disease (PD). Methods: By using …

Parkinson's disease is a devastating neurodegenerative disorder affecting 2-3% of the
population over 65 years of age. There is currently no disease-modifying treatment. One of …

Dopaminergic neurons are involved in a variety of normal brain functions; degenerations of
these neurons cause diseases in human. Investigation of how dopaminergic neurons …

Stem cells have been suggested as candidate therapeutic tools for neurodegenerative
disorders, given their ability to give rise to the appropriate cell types after grafting in vivo. In …

Our ability to use human embryonic stem (hES) cells in cell replacement therapy for
Parkinson's disease depends on the discovery of ways to simply and reliably differentiate a …

We have developed an efficient approach to generate functional induced dopaminergic (DA)
neurons from adult human dermal fibroblasts. When performing DA neuronal conversion of …

Understanding the mechanisms causing Parkinson's disease (PD) is vital to the
development of much needed early diagnostics and therapeutics for this debilitating …

One of the prospects for a curative treatment for Parkinson's disease is to replace the lost
dopaminergic neurons. Preclinical and clinical trials have demonstrated that dissected fetal …