Current multiple sclerosis treatments have improved our understanding of MS autoimmune pathogenesis

R Martin, M Sospedra, M Rosito… - European journal of …, 2016 - Wiley Online Library
Multiple sclerosis (MS) is the most common inflammatory disorder of the central nervous
system (CNS) in young adults. When MS is not treated, it leads to irreversible and severe …

Immunopathogenesis of multiple sclerosis

M Comabella, SJ Khoury - Clinical immunology, 2012 - Elsevier
Multiple sclerosis (MS) is a chronic disorder of the central nervous system characterized by
autoimmune inflammation, demyelination, and axonal damage. MS etiology remains …

Immunomodulation in multiple sclerosis: promises and pitfalls

CA Dendrou, L Fugger - Current opinion in immunology, 2017 - Elsevier
Highlights•Multiple sclerosis (MS) is an autoimmune disorder of the brain and spinal cord.•
Immunomodulatory drugs have been used for over two decades to treat relapsing MS.•Their …

Multiple sclerosis: immune mechanism and update on current therapies

S Bansil, SD Cook… - Annals of Neurology …, 1995 - Wiley Online Library
Multiple sclerosis (MS) is a demyelinating disease of the central nervous system (CNS)
afflicting approximately 250,000 individuals in the United States. This inflammatory disease …

Which immune cells matter? The immunopathogenesis of multiple sclerosis

B Broux, P Stinissen, N Hellings - Critical Reviews™ in …, 2013 - dl.begellhouse.com
Multiple sclerosis (MS) is a complex disease of the central nervous system (CNS), which is
believed to be immune-mediated. While CD4+ T cells have been the main suspects for …

Update on immunopathogenesis and immunotherapy in multiple sclerosis

RC Selter, B Hemmer - ImmunoTargets and therapy, 2013 - Taylor & Francis
Multiple sclerosis is a chronic inflammatory demyelinating disease of the central nervous
system. Both genetic and environmental factors are believed to contribute to the …

Current and future therapies targeting the immune system in multiple sclerosis

V Loleit, V Biberacher, B Hemmer - Current Pharmaceutical …, 2014 - ingentaconnect.com
Multiple sclerosis (MS) is a demyelinating disease of the central nervous system (CNS). The
exact pathomechanism is unknown, but an aberrant immune response against CNS …

Multiple sclerosis: mechanisms and immunotherapy

C Baecher-Allan, BJ Kaskow, HL Weiner - Neuron, 2018 - cell.com
Multiple sclerosis (MS) is an autoimmune disease triggered by environmental factors that act
on a genetically susceptible host. It features three clinical stages: a pre-clinical stage …

Insights into the immunopathogenesis of multiple sclerosis

N Hellings, J Raus, P Stinissen - Immunologic research, 2002 - Springer
Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system
(CNS). Significant progress has been made in our understanding of the etiology of MS. MS …

Multiple sclerosis: a practical overview for clinicians

K Rejdak, S Jackson, G Giovannoni - British medical bulletin, 2010 - academic.oup.com
Multiple sclerosis (MS) is the commonest disabling neurological condition to afflict young
adults and therefore has a high social burden. Over several decades, there has been a …