Processed BNP Molecular Forms As A New Generation Biomarker In Cardiovascular Disease

MZ Israr - 2019 - figshare.le.ac.uk
B-type natriuretic peptide (BNP), a clinical biomarker for cardiovascular disease (CVD), is
secreted by cardiac tissue in response to neurohormonal stresses. However, BNP is …

B-type natriuretic peptide molecular forms for risk stratification and prediction of outcome after acute myocardial infarction

MZ Israr, LM Heaney, LL Ng, T Suzuki - American heart journal, 2018 - Elsevier
Background B-type natriuretic peptide (BNP) is known to be a risk marker following acute
myocardial infarction (MI). More recently, truncated molecular forms of the BNP molecule …

Amino-terminal pro-B-type natriuretic peptide and B-type natriuretic peptide: biomarkers for mortality in a large community-based cohort free of heart failure

PM McKie, RJ Rodeheffer, A Cataliotti, FL Martin… - …, 2006 - Am Heart Assoc
Recent studies report that, in the absence of heart failure and renal failure, plasma B-type
natriuretic peptide (BNP) has prognostic value for mortality. We sought to confirm and extend …

Development and validation of an IA-LC/MS method to quantitate active and total B-type natriuretic peptide in human plasma

DL Chappell, AYH Lee, HS Bernstein, ME Lassman… - Bioanalysis, 2016 - Taylor & Francis
Aim: Patients with elevated levels of B-type natriuretic peptide (BNP) and/or NT-proBNP as
measured by clinical tests have an elevated risk of heart failure (HF). Despite utility in large …

Prognostic role of molecular forms of B-type natriuretic peptide in acute heart failure

T Suzuki, MZ Israr, LM Heaney, M Takaoka… - Clinical …, 2017 - academic.oup.com
BACKGROUND B-type natriuretic peptide (BNP) molecular forms 5-32, 4-32, and 3-32 are
known to be present in the circulation of heart failure (HF) patients. This study investigated …

[引用][C] Natriuretic peptides–Biomarker companions through thick and thin

MT Maeder - European Journal of Heart Failure, 2024 - Wiley Online Library
B-type natriuretic peptide (BNP) is produced by cardiomyocytes and promotes natriuresis
and vasodilatation and thereby counteracts the deleterious effects of the sympathetic …

[HTML][HTML] Searching for a BNP standard: Glycosylated proBNP as a common calibrator enables improved comparability of commercial BNP immunoassays

AG Semenov, NN Tamm, FS Apple, KM Schulz… - Clinical …, 2017 - Elsevier
Background Circulating B-type natriuretic peptide (BNP) is widely accepted as a diagnostic
and risk assessment biomarker of cardiac function. Studies suggest that there are significant …

[PDF][PDF] B-Type Natriuretic Peptides and Cardiovascular Risk

N Sattar, F John Danesh - Circulation, 2009 - academia.edu
Background—Measurement of B-type natriuretic peptide (BNP) concentration or its
precursor (N-terminal fragment [NT-proBNP]) is recommended in patients with symptoms of …

B-type natriuretic peptide as a biomarker beyond heart failure: speculations and opportunities

PM McKie, JC Burnett Jr - Mayo Clinic Proceedings, 2005 - Elsevier
Cardiac secretion of B-type natriuretic peptide (BNP) increases with the progression of heart
failure (HF), and plasma measurement of BNP has emerged recently as a useful, cost …

B-Type Natriuretic Peptide (BNP) Revisited—Is BNP Still a Biomarker for Heart Failure in the Angiotensin Receptor/Neprilysin Inhibitor Era?

T Nishikimi, Y Nakagawa - Biology, 2022 - mdpi.com
Simple Summary Active BNP-32, less active proBNP-108, and inactive N-terminal proBNP-
76 all circulate in the blood. The circulating protease neprilysin has lower substrate …