Epigenetic processes are essential for normal development and the maintenance of tissue-
specific gene expression in mammals. Changes in gene expression and malignant cellular …

Histone modifications are an epigenetic mechanism, and the dysregulation of these proteins
is known to be associated with the initiation and progression of cancer. In the search for the …

Posttranslational methylation of histones plays a critical role in gene regulation.
Misregulation of histone methylation can lead to oncogenic transformation. Enhancer of …

Epigenetic regulatory enzymes are generally considered innovative targets for cancer
therapy and several histone methyltransferase inhibitors are currently being evaluated in …

Histone proteins are subject to a diverse range of post-translational modifications which,
along with DNA methylation, play a major role in controlling gene expression, cell division …

Epigenetics is defined as heritable changes in gene activity and expression that occur
without alteration in DNA sequence. The gene transcription is strictly correlated to chromatin …

Post-translational methylation of histone lysine or arginine residues plays important roles in
gene regulation and other physiological processes. Aberrant histone methylation caused by …

Targeting chromatin-modifying enzymes is a promising strategy for cancer treatment. The
antitumor effectivity of compounds inhibiting histone methyltransferases—mainly EZH2—is …

Abnormalities in the epigenetic regulation of chromatin structure and function can lead to
aberrant gene expression and cancer development. Consequently, epigenetic therapies aim …

Cancer in humans is the result of a multi-step process. This process often involves the
activation of oncogenes and/or the inactivation of tumor suppressor genes. These two steps …