Numerous inflammatory skin disorders display a high prevalence of itch. The Mas-related G
protein coupled receptor X2 (MRGPRX2) has been shown to modulate itch by inducing non …

Mast cells are tissue-resident innate immune cells known for their prominent role in
mediating allergic reactions. MAS-related G-protein coupled receptor-X2 (MRGPRX2) is a …

Classical itch studies have focused on immunoglobulin E (IgE)-mediated mast cell activation
and histamine release. Recently, members of the Mas-related G-protein-coupled receptor …

Background: Mast cells are considered an attractive therapeutic target for treating allergic
diseases, and the Lyn–FcεRIβ interaction is essential for mast cell activation. This study …

Atopic dermatitis has been described as the itch that rashes. Indeed, the itching associated
with the condition is often considered to be the most challenging feature of the disease to …

Background Phytosphingosine and its derivative are known for their skin-protective
properties. While mYG-II-6, a phytosphingosine derivative, has shown anti-inflammatory and …

Itch is an unpleasant sensation that often accompanies chronic dermatological conditions.
Although many of the itch receptors and the neural pathways underlying this sensation are …

MRGPRX2, a G-protein-coupled-seven transmembrane domain receptor, is mainly
expressed in mast cells and neurons and is involved in skin immunity and pain. It is …

Itch has been defined as an unpleasant skin sensation that triggers the urge to scratch.
Primary sensory dorsal root ganglia neurons detect itch stimuli through peripheral axons in …

Mast cells are innate immune cells that intersect with the adaptive immunity and play a
crucial role in the initiation of allergic reactions and the host defense against certain …