[HTML][HTML] Signaling pathways in Parkinson's disease: molecular mechanisms and therapeutic interventions

X Dong-Chen, C Yong, X Yang, ST Chen-Yu… - Signal transduction and …, 2023 - nature.com
Parkinson's disease (PD) is the second most common neurodegenerative disease
worldwide, and its treatment remains a big challenge. The pathogenesis of PD may be …

[HTML][HTML] Promising drug targets and associated therapeutic interventions in Parkinson's disease

SN Rai, P Singh, R Varshney… - Neural regeneration …, 2021 - journals.lww.com
Parkinson's disease (PD) is one of the most debilitating brain diseases. Despite the
availability of symptomatic treatments, response towards the health of PD patients remains …

[HTML][HTML] Multifunctional role of natural products for the treatment of Parkinson's disease: at a glance

MM Rahman, X Wang, MR Islam, S Akash… - Frontiers in …, 2022 - frontiersin.org
Natural substances originating from plants have long been used to treat neurodegenerative
disorders (NDs). Parkinson's disease (PD) is a ND. The deterioration and subsequent …

[HTML][HTML] Neuroprotective and therapeutic strategies against Parkinson's disease: recent perspectives

S Sarkar, J Raymick, S Imam - International journal of molecular sciences, 2016 - mdpi.com
Parkinsonism is a progressive motor disease that affects 1.5 million Americans and is the
second most common neurodegenerative disease after Alzheimer's. Typical …

Parkinson's disease: Mechanisms, translational models and management strategies

C Raza, R Anjum - Life sciences, 2019 - Elsevier
Parkinson's disease is a progressive neurodegenerative disorder. The classical motor
symptoms include resting tremors, bradykinesia, rigidity and postural instability and are …

Current pharmaceutical treatments and alternative therapies of Parkinson's disease

J Dong, Y Cui, S Li, W Le - Current neuropharmacology, 2016 - ingentaconnect.com
Over the decades, pharmaceutical treatments, particularly dopaminergic (DAergic) drugs
have been considered as the main therapy against motor symptoms of Parkinson's disease …

Parkinson's disease: a short story of 200 years

L Cuenca, AL Gil Martinez, L Cano Fernandez… - 2019 - digitum.um.es
After Alzheimer's disease, Parkinson's disease (PD) is the second most prevalent and
incidental neurodegenerative disorder, affecting more than 2% of the population older than …

[HTML][HTML] Triggers, facilitators, and aggravators: redefining Parkinson's disease pathogenesis

ME Johnson, B Stecher, V Labrie, L Brundin… - Trends in …, 2019 - cell.com
We hypothesize that Parkinson's disease (PD) pathogenesis can be divided into three
temporal phases. During the first phase,'triggers', such as viral infections or environmental …

[HTML][HTML] Parkinson's disease-implicated kinases in the brain; insights into disease pathogenesis

N Dzamko, J Zhou, Y Huang… - Frontiers in molecular …, 2014 - frontiersin.org
Substantial evidence implicates abnormal protein kinase function in various aspects of
Parkinson's disease (PD) etiology. Elevated phosphorylation of the PD-defining pathological …

[HTML][HTML] Emerging therapeutic strategies for Parkinson's disease and future prospects: a 2021 update

NA Gouda, A Elkamhawy, J Cho - Biomedicines, 2022 - mdpi.com
Parkinson's disease (PD) is a neurodegenerative disorder pathologically distinguished by
degeneration of dopaminergic neurons in the substantia nigra pars compacta. Muscle …