Objective: The associations of vascular risk factors (VRFs), apolipoprotein E (APOE), and
translocase of outer mitochondrial membrane 40 (TOMM40) with cognitive function have …

Abstract Background The apolipoprotein E (APOE) ε4 allele is a strong risk factor for
Alzheimer's disease (AD) in Caucasian and African American populations. It suggests that …

Mitochondrial dysfunction is an early defect in the pathogenesis of late-onset Alzheimer's
disease (LOAD). One interesting candidate gene for mitochondrial dysfunction in LOAD is …

INTRODUCTION: A highly polymorphic T homopolymer was recently found to be associated
with late-onset Alzheimer's disease risk and age of onset. OBJECTIVE: To explore the …

Genetic studies have identified Alzheimer's disease (AD)-associated SNPs in TOMM40 and
PVRL2 genes, but the underlying mechanisms remain unknown. We examined their …

The very long (VL) poly-T variant at rs10524523 (“523”) of the TOMM40 gene may hasten
the onset of late-onset Alzheimer's disease (LOAD) and induce more profound cognitive …

Introduction: There is empirical evidence that cardiovascular risk factors and vascular
pathology contribute to cognitive impairment and dementia. Methods: We profiled …

Background Several researchers have suggested that the rs2075650 polymorphism is
significantly associated with an increased risk of developing Alzheimer disease (AD) in …

Largescale genome-wide association studies (GWAS) showed that the TOMM40 rs2075650
polymorphism is significantly associated with Alzheimer's disease (AD) in Caucasian …

The variable length poly-T, rs10524523 ('523') located within the TOMM40 gene, was
recently associated with several phenotypes of cognitive function. The short (S) allele is …