Targeted subcellular protein delivery using cleavable cyclic cell-penetrating peptides

AFL Schneider, ALD Wallabregue, L Franz… - Bioconjugate …, 2019 - ACS Publications
The delivery of entire functional proteins into living cells is a long-sought goal in science.
Cyclic cell-penetrating peptides (cCPPs) have proven themselves to be potent delivery …

Identification of short hydrophobic cell-penetrating peptides for cytosolic peptide delivery by rational design

S Schmidt, MJW Adjobo-Hermans, R Kohze… - Bioconjugate …, 2017 - ACS Publications
Cell-penetrating peptides (CPPs) enhance the cellular uptake of membrane-impermeable
molecules. Most CPPs are highly cationic, potentially increasing the risk of toxic side effects …

Cell-penetrating peptides as delivery vehicles for biology and medicine

KM Stewart, KL Horton, SO Kelley - Organic & biomolecular chemistry, 2008 - pubs.rsc.org
Cell-penetrating peptides (CPPs) have found numerous applications in biology and
medicine since the first synthetic cell-permeable sequence was identified two decades ago …

[HTML][HTML] A versatile cell-penetrating peptide-adaptor system for efficient delivery of molecular cargos to subcellular destinations

VM Ngwa, DS Axford, AN Healey, SJ Nowak… - PloS one, 2017 - journals.plos.org
Cell penetrating peptides have long held great potential for delivery of biomolecular cargos
for research, therapeutic and diagnostic purposes. They allow rapid, relatively nontoxic …

[HTML][HTML] Considerations on the rational design of covalently conjugated cell-penetrating peptides (CPPs) for intracellular delivery of proteins: a guide to CPP selection …

Y Behzadipour, S Hemmati - Molecules, 2019 - mdpi.com
Access of proteins to their intracellular targets is limited by a hydrophobic barrier called the
cellular membrane. Conjugation with cell-penetrating peptides (CPPs) has been shown to …

Covalent attachment of cyclic TAT peptides to GFP results in protein delivery into live cells with immediate bioavailability

N Nischan, HD Herce, F Natale… - Angewandte Chemie …, 2015 - Wiley Online Library
The delivery of free molecules into the cytoplasm and nucleus by using arginine‐rich cell‐
penetrating peptides (CPPs) has been limited to small cargoes, while large cargoes such as …

Enhanced live‐cell delivery of synthetic proteins assisted by cell‐penetrating peptides fused to DABCYL

S Mandal, G Mann, G Satish… - Angewandte Chemie …, 2021 - Wiley Online Library
Live‐cell delivery of a fully synthetic protein having selectivity towards a particular target is a
promising approach with potential applications for basic research and therapeutics. Cell …

Cell-penetrating peptides as nucleic acid delivery systems: from biophysics to biological applications

S Trabulo, AL Cardoso, A MS Cardoso… - Current …, 2013 - ingentaconnect.com
The increasing knowledge on the genetic basis of disease has allowed the development of
promising gene-targeted therapies that can be applied to numerous diseases. Such genetic …

[HTML][HTML] Recent advances in selective and targeted drug/gene delivery systems using cell-penetrating peptides

SH Nam, J Park, H Koo - Archives of Pharmacal Research, 2023 - Springer
Biological cell membranes are a natural barrier for living cells. In the last few decades, the
cell membrane has been the main hurdle in the efficient delivery of bioactive and therapeutic …

Cell-penetrating peptides with intracellular organelle targeting

CP Cerrato, K Künnapuu, Ü Langel - Expert opinion on drug …, 2017 - Taylor & Francis
Introduction: One of the major limiting steps in order to have an effective drug is the passage
through one or more cell membranes to reach its site of action. To reach the action-site, the …