While IL-12 plays a key role in differentiation of protective CD4+ Th1 response, little is
known about mechanisms whereby IL-12 differentiates other T-cell populations. Published …

Differentiation, distribution and immune regulation of human IL-22-producing T cells in
infections remain unknown. Here, we demonstrated in a nonhuman primate model that M …

Abstract Vγ9/Vδ2 T cells are a minor subset of T cells in human blood and differ from all
other lymphocytes by their specific responsiveness to (E)‐4‐hydroxy‐3‐methyl‐but‐2‐enyl …

T cell cytokines contribute to immunity against Staphylococcus aureus, but the predominant
T cell subsets involved are unclear. In an S. aureus skin infection mouse model, we found …

The host acquired immune response, especially the humoral immunity, plays key roles in
preventing bacterial pneumonia in the lung. Our previous research demonstrated that …

In healthy adults, the major peripheral blood γδ T-cell subset expresses the Vγ9Vδ2 TCR
and displays pleiotropic features. Here we report that coculture of naive Vγ9Vδ2 T cells with …

ABSTRACT Interleukin-17A (IL-17A)-producing γδ T cells are known to be activated
following Mycobacterium bovis bacillus Calmette-Guérin (BCG) infection. Here, we show …

Murine γ δ T cells participate in innate immune response against infection of the intracellular
bacterium Listeria monocytogenes. In the present report, we analyzed the mechanism of the …

Interleukin (IL)-12 is a multifunctional cytokine acting as a key regulator of cell-mediated
immune responses through the differentiation of naïve CD4+ T cells into type 1 helper T cells …

Vδ2Vγ9 T cells are the dominant γδ T-cell subset in human peripheral blood. Vδ2 T cells
recognize pyrophosphate molecules derived from microbes or tumor cells; hence, they play …