Novel therapeutics for patients with well-differentiated gastroenteropancreatic neuroendocrine tumors

S Das, A Dasari - Therapeutic advances in medical oncology, 2021 - journals.sagepub.com
Gastroenteropancreatic (GEP) neuroendocrine tumors (NETs) represent the most common
subtype of NETs. The incidence of all NETs, and specifically GEP NETs, has risen …

The emerging role of targeted therapies for advanced well-differentiated gastroenteropancreatic neuroendocrine tumors

JM Cloyd, B Konda, MH Shah… - Expert Review of Clinical …, 2019 - Taylor & Francis
Introduction: Gastroenteropancreatic (GEP) neuroendocrine tumors (NETs) are unique and
complex neoplasms, exhibiting a wide spectrum of diverse clinical behaviors. The …

[HTML][HTML] Immunotherapies for well-differentiated grade 3 gastroenteropancreatic neuroendocrine tumors: A new category in the World Health Organization …

JX Xu, DH Wu, LW Ying, HG Hu - World Journal of …, 2021 - ncbi.nlm.nih.gov
Abstract According to the 2019 World Health Organization (WHO) classification, well-
differentiated grade 3 (G3) gastroenteropancreatic (GEP) neuroendocrine tumors (NETs) are …

177Lu-DOTATATE for the treatment of gastroenteropancreatic neuroendocrine tumors

S Das, T Al-Toubah, G El-Haddad… - Expert review of …, 2019 - Taylor & Francis
ABSTRACT Introduction: 177Lutetium-[DOTA°, Tyr3] octreotate (177Lu-DOTATATE) is a
type of peptide receptor radionuclide therapy that garnered FDA approval in January 2018 …

[HTML][HTML] Combination systemic therapies in advanced well-differentiated gastroenteropancreatic neuroendocrine tumors (GEP-NETs): A comprehensive review of …

LN Diamantopoulos, M Kalligeros, TR Halfdanarson… - Biology, 2023 - mdpi.com
Simple Summary This comprehensive review explores evolving systemic combination
regimens for advanced well-differentiated gastroenteropancreatic neuroendocrine tumors …

Pivotal phase III COMPOSE trial will compare 177Lu-edotreotide with best standard of care for well-differentiated aggressive grade 2 and grade 3 …

TR Halfdanarson, DL Reidy, N Vijayvergia… - 2022 - ascopubs.org
TPS514 Background: Gastroenteropancreatic neuroendocrine tumors (GEP-NETs), which
represent approximately 70% of NETs, frequently develop metastatic disease with limited …

Role of immunotherapy in gastro‐enteropancreatic neuroendocrine neoplasms (gep‐nens): Current advances and future directions

L Fang, D Arvind, A Dowlati… - Journal of …, 2021 - Wiley Online Library
Neuroendocrine neoplasms (NENs) are heterogeneous tumours originating from
neuroendocrine cells (Pearse & Polak, Gut, 1971, 12,783). They were once considered as …

Medical management of gastroenteropancreatic neuroendocrine tumors: current strategies and future advances

A Mohamed, JR Strosberg - Journal of nuclear medicine, 2019 - Soc Nuclear Med
Gastroenteropancreatic neuroendocrine tumors are relatively rare neoplasms, characterized
by a propensity to secrete hormones that cause distinct clinical syndromes. During the past …

Resistant functioning and/or progressive symptomatic metastatic gastroenteropancreatic neuroendocrine tumors: efficacy of: 177: Lu-DOTATATE peptide receptor …

A Kalshetty, A Ramaswamy, V Ostwal… - Nuclear medicine …, 2018 - journals.lww.com
Materials and methods A total of 46 patients with refractory or progressive symptomatic GEP-
NETs (previously treated at various stages with long-acting octreotide, chemotherapy …

Hematological Toxicity of Combined 177Lu-Octreotate Radiopeptide Chemotherapy of Gastroenteropancreatic Neuroendocrine Tumors in Long-Term Follow-Up

M Kesavan, PG Claringbold, JH Turner - Neuroendocrinology, 2014 - karger.com
Background: The combination of radiopeptide therapy [peptide receptor radionuclide
therapy (PRRT)] with radiosensitizing chemotherapy of gastroenteropancreatic …