The use of natural compounds as a strategy to counteract oxidative stress in animal models of diabetes mellitus

M Salazar-García, JC Corona - International Journal of Molecular …, 2021 - mdpi.com
Diabetes mellitus (DM) is a chronic metabolic disease characterised by insulin deficiency,
resulting in hyperglycaemia, a characteristic symptom of type 2 diabetes mellitus (DM2). DM …

Mechanistic insights into diabetes mellitus and oxidative stress

K Maiese, ZZ Chong, YC Shang - Current medicinal chemistry, 2007 - ingentaconnect.com
Diabetes mellitus (DM) is a significant healthcare concern worldwide that affects more than
165 million individuals leading to cardiovascular disease, nephropathy, retinopathy, and …

Reactive species and diabetes: counteracting oxidative stress to improve health

P Pérez-Matute, MA Zulet, JA Martínez - Current opinion in pharmacology, 2009 - Elsevier
Oxidative stress is at the very core of metabolism. Reactive species behave as true second
messengers that control important cellular functions. However, under pathological …

Development and discovery avenues in bioactive natural products for glycemic novel therapeutics

SR Naik, GR Kokil - Studies in natural products chemistry, 2013 - Elsevier
Bioactive natural products are an excellent source of novel therapeutics. The search for
bioactive molecules from nature continues to play a major role in developing new …

Reduction of oxidative stress by a new low-molecular-weight antioxidant improves metabolic alterations in a nonobese mouse diabetes model

M Novelli, V D'Aleo, R Lupi, M Paolini, A Soleti… - Pancreas, 2007 - journals.lww.com
Objectives: We have previously established a nonobese diabetes mouse model
characterized by moderate hyperglycemic levels, like those usually occurring in human type …

Antioxidant effects and mechanisms of medicinal plants and their bioactive compounds for the prevention and treatment of type 2 diabetes: an updated review

JO Unuofin, SL Lebelo - Oxidative medicine and cellular …, 2020 - Wiley Online Library
Diabetes mellitus is a metabolic disorder that majorly affects the endocrine gland, and it is
symbolized by hyperglycemia and glucose intolerance owing to deficient insulin secretory …

Bioactive agent discovery from the natural compounds for the treatment of type 2 diabetes rat model

SC Yang, CY Hsu, WL Chou, JY Fang, SY Chuang - Molecules, 2020 - mdpi.com
Diabetes mellitus is a well-known chronic metabolic disease that poses a long-term threat to
human health and is characterized by a relative or absolute lack of insulin, resulting in …

[PDF][PDF] Oxidative stress and diabetes: an overview

K Sireesha, SP Rao - Asian J Pharm Clin Res, 2015 - academia.edu
Oxidative stress is well known to be involved in the pathogenesis of lifestyle related
diseases. Oxidative stress contributes to many pathological conditions including cancer …

Animal models for assessing the impact of natural products on the aetiology and metabolic pathophysiology of Type 2 diabetes

M Asrafuzzaman, Y Cao, R Afroz, D Kamato… - Biomedicine & …, 2017 - Elsevier
Type 2 diabetes mellitus is a complex and heterogeneous disorder which in its most
common manifestation arises from insulin resistance and later insulin insufficiency. Type 2 …

Role of dietary and endogenous antioxidants in diabetes

G Marrazzo*, I Barbagallo*, F Galvano… - Critical reviews in …, 2014 - Taylor & Francis
Diabetes affects different people of all ages, race, and sex. This is a condition characterized
by a state of chronic hyperglycaemia that leads to an increase of intracellular oxidative …