Apart from its known actions as a pulmonary vasodilator, nitric oxide (NO) is a key signal
mediator in the neonatal brain. Despite the extensive use of NO for pulmonary artery …

Nitric oxide (NO) has critical roles in a wide variety of key biologic functions and has intricate
transport mechanisms for delivery to key distal tissues under normal conditions. However …

Inhaled nitric oxide (iNO) is a therapy used in neonates with pulmonary hypertension. Some
evidence of its neuroprotective properties has been reported in both mature and immature …

Fetal ischemia or hypoxia can lead to cerebral palsy, mental retardation and epilepsy. We
propose that the production of nitric oxide and oxygen radicals by neurons when ischemic or …

Although inhaled nitric oxide–mediated decreases in chronic lung disease and severe
intraventricular hemorrhage/periventricular leukomalacia undoubtedly contribute to …

Nitric oxide (NO) is a key signalling molecule in the regulation of cerebral blood flow. This
review summarises current evidence regarding the role of NO in the regulation of cerebral …

The role of NO in the neonatal brain, particularly during hypoxia and ischaemia has been
studied extensively in animal models of focal and global ischaemia. The n-NOS and i-NOS …

Hypoxic-ischemic brain damage remains an outstanding cause of death and long-lasting
disabilities for newborns worldwide. Among the different constituents of the complex …

Inhaled nitric oxide (iNO) is one of the most promising therapies used in neonates, but there
is little information available about its effect on the developing brain. We explored the effects …

Publisher Summary A variety of mechanisms have been proposed for NO neurotoxicity,
including inhibition of mitochondrial enzymes such as cis-aconitase, inhibition of the …