A Study on the Clinical Relevance of Metalloproteinase Inhibition
L Onwuha-Ekpete - 2020 - search.proquest.com
The Metzincins are a superfamily of zinc-dependent endopeptidases associated with the
regulation of the extracellular matrix (ECM). Their members include A Disintegrin and …
regulation of the extracellular matrix (ECM). Their members include A Disintegrin and …
Other MMPs and Their Inhibitors
Other matrix metalloproteinases (MMPs) are grouped into separate categories, including
MMP-12, MMP-19, MMP-20, MMP-21, MMP-27, and MMP-28. These MMPs have yet to …
MMP-12, MMP-19, MMP-20, MMP-21, MMP-27, and MMP-28. These MMPs have yet to …
Zinc–metalloproteinase inhibitors: Evaluation of the complex role played by the zinc-binding group on potency and selectivity
C Rouanet-Mehouas, B Czarny, F Beau… - Journal of medicinal …, 2017 - ACS Publications
The most exploited strategy to develop potent zinc–metalloprotease inhibitors relies on a
core zinc chelator and a peptidic or nonpeptidic scaffold that provides supplementary …
core zinc chelator and a peptidic or nonpeptidic scaffold that provides supplementary …
The significance of the Cα substituent in the selective inhibition of matrix metalloproteinases 1 and 9
R Domingo, K Chibale, ED Sturrock - 2011 - degruyter.com
Matrix metalloproteinases (MMPs) cleave and degrade most components of the extracellular
matrix, and unregulated MMP activity has been correlated to cancer and metastasis. Hence …
matrix, and unregulated MMP activity has been correlated to cancer and metastasis. Hence …
Spontaneous propeptide processing of mini-stromelysin-1 mutants blocked by APMA ((4-Aminophenyl) mercuric acetate)
G Galazka, LJ Windsor, H Birkedal-Hansen… - Biochemistry, 1999 - ACS Publications
Human stromelysin-1 (SL-1) is a member of the stromelysin subfamily of matrix
metalloproteinases (MMPs). The MMPs play a major role in the degradation of the …
metalloproteinases (MMPs). The MMPs play a major role in the degradation of the …
[引用][C] PROTEIN STRUCTURE AND FOLDING-The 1.8-A crystal structure of a matrix metalloproteinase 8-barbiturate inhibitor complex reveals a previously …
H Brandstetter, F Grams, D Glitz, A Lang… - Journal of Biological …, 2001 - Baltimore [etc.]
[HTML][HTML] Next generation matrix metalloproteinase inhibitors—Novel strategies bring new prospects
Enzymatic proteolysis of cell surface proteins and extracellular matrix (ECM) is critical for
tissue homeostasis and cell signaling. These proteolytic activities are mediated …
tissue homeostasis and cell signaling. These proteolytic activities are mediated …
A bioinorganic perspective on matrix metalloproteinase inhibition
DT Puerta, SM Cohen - Current Topics in Medicinal Chemistry, 2004 - ingentaconnect.com
The zinc-dependent enzymes known as matrix metalloproteinases (MMPs) are medicinal
targets due to the activity of these enzymes associated with diseases such as cancer, heart …
targets due to the activity of these enzymes associated with diseases such as cancer, heart …
Mechanistic studies on the human matrix metalloproteinase stromelysin
RK Harrison, B Chang, L Niedzwiecki, RL Stein - Biochemistry, 1992 - ACS Publications
MATERIALS AND METHODS General. Peptide substrates were purchased from Bachem
(Philadelphia, PA) at a purity greater than 98%. Water was purified through a Millipore Milli …
(Philadelphia, PA) at a purity greater than 98%. Water was purified through a Millipore Milli …
Matrix metalloproteinase protein inhibitors: highlighting a new beginning for metalloproteinases in medicine
V Mohan, D Talmi-Frank, V Arkadash… - Metalloproteinases in …, 2016 - Taylor & Francis
The development of therapeutic matrix metalloproteinase (MMP) inhibitors has evolved from
broad-spectrum peptidomimetic inhibitors with deleterious side effects, to highly selective …
broad-spectrum peptidomimetic inhibitors with deleterious side effects, to highly selective …