Humanized mice can be used to better understand how the human immune system
responds to central nervous system (CNS) injury and inflammation. The optimal parameters …

Background Immune cells play crucial roles after spinal cord injury (SCI). However,
incomplete knowledge of immune contributions to injury and repair hinders development of …

Spinal cord injury (SCI) represents a major medical challenge. At present, there is still no
cure to treat it efficiently and enable functional recovery below the injury site. Previously, we …

In order to determine if a specific response is induced after spinal cord injury, we performed
a kinetic search for IgG antibodies against various spinal cord antigenic preparations in a rat …

Numerous mechanisms contribute to neural damage following central nervous system
(CNS) injury. Inflammatory response has emerged as an important interaction between the …

Injuries to the central nervous system (CNS) trigger an inflammatory reaction with potentially
devastating consequences. In this report we compared the characteristics of the …

Spinal cord injury (SCI) leads to irreversible devastating neurological disabilities.
Accumulated evidence in the literature indicates that the inflammatory response that occurs …

Historically, the immune response after spinal cord injury was considered largely detrimental
owing to the release of neurotoxic factors. While there is validity to this view, there is much …

Spinal cord injury (SCI) is a devastating neurological condition prevalent worldwide. Where
the pathological mechanisms underlying SCI are concerned, we can distinguish between …

Background Spinal cord injury (SCI) is a condition with few effective treatment options. The
blood-spinal cord barrier consists of pericytes, astrocytes, and endothelial cells, which are …