Mixed affective states, defined as the coexistence of depressive and manic symptoms, are
complex presentations of manic-depressive illness that represent a challenge for clinicians …

OBJECTIVE: Failure to recognize bipolar disorder in patients who experience a major
depressive episode may lead to inappropriate treatment and poorer outcomes. Clinical …

Bipolar disorder is a mood disorder which requires complex treatment. Current treatment
guidelines are based on the results of published randomized clinical trials and meta …

Mixed states in bipolar disorder have been neglected, and the data concerning treatment of
these conditions have been relatively obscure. To address this, we systematically reviewed …

Background To describe the frequency of mixed specifier as proposed in DSM-5 in bipolar I
patients with manic episodes, and to evaluate the effect of mixed specifier on symptom …

Objectives: Bipolar disorder is often misdiagnosed as major depressive disorder. Such
misdiagnosis partly depends on the type of treatment setting. This study compared general …

Bipolar disorder, also known as manic-depressive disorder, is a prevalent, disabling, and
chronic condition. Bipolar disorder is defined by periods of mood instability defined by the …

In recent years, combinations of pharmacological treatments have become common for the
treatment of bipolar disorder type I (BP I); however, this practice is usually not evidence …

Background Many new approaches have been adopted for the treatment of bipolar disorder
(BD) in the past few years, which strived to produce more positive outcomes. To enhance the …

Manic and mixed episodes can be challenging to treat despite published guidelines and
algorithms. An alternative iterative approach that offers evidence-based treatment options at …