Mechanisms, pathophysiology and currently proposed treatments of chronic obstructive pulmonary disease

SO Rodrigues, CMC Cunha, GMV Soares, PL Silva… - Pharmaceuticals, 2021 - mdpi.com
Chronic obstructive pulmonary disease (COPD) is one of the leading global causes of
morbidity and mortality. A hallmark of COPD is progressive airflow obstruction primarily …

Future research directions in chronic obstructive pulmonary disease

TL Croxton, GG Weinmann, RM Senior… - American journal of …, 2002 - atsjournals.org
Between 3 and 7 million Americans are currently diagnosed with chronic obstructive
pulmonary disease (COPD), and the true prevalence is probably greater than 16 million (1) …

Pharmacological treatment of chronic obstructive pulmonary disease: from evidence-based medicine to phenotyping

P Montuschi, M Malerba, G Santini, M Miravitlles - Drug discovery today, 2014 - Elsevier
Highlights•Several phenotypes characterize chronic obstructive pulmonary disease
(COPD).•Response to pharmacological treatment in COPD is highly variable.•Guidelines …

Recent advances in chronic obstructive pulmonary disease pathogenesis: from disease mechanisms to precision medicine

CA Brandsma, M Van den Berge… - The Journal of …, 2020 - Wiley Online Library
Chronic obstructive pulmonary disease (COPD) is a devastating lung disease with a high
personal and societal burden. Exposure to toxic particles and gases, including cigarette …

Future therapeutic treatment of COPD: struggle between oxidants and cytokines

WI de Boer, H Yao, I Rahman - International journal of chronic …, 2007 - Taylor & Francis
Chronic obstructive pulmonary disease (COPD) is a global health problem. Being a
progressive disease characterized by inflammation and predominantly caused by tobacco …

COPD: is there light at the end of the tunnel?

PJ Barnes - Current opinion in pharmacology, 2004 - Elsevier
No currently available treatments reduce the progression or suppress the inflammation of
chronic obstructive pulmonary disease (COPD). However, with a better understanding of the …

Current controversies in the pharmacological treatment of chronic obstructive pulmonary disease

D Singh, N Roche, D Halpin, A Agusti… - American journal of …, 2016 - atsjournals.org
Clinical phenotyping is currently used to guide pharmacological treatment decisions in
chronic obstructive pulmonary disease (COPD), a personalized approach to care. Precision …

New concepts in chronic obstructive pulmonary disease

PJ Barnes - Annual review of medicine, 2003 - annualreviews.org
Chronic obstructive pulmonary disease (COPD) is a leading cause of death and disability
but has only recently been explored from a cellular and molecular perspective. In COPD …

Advances in chronic obstructive pulmonary disease

MC Ferrera, WW Labaki, MLK Han - Annual review of medicine, 2021 - annualreviews.org
Chronic obstructive pulmonary disease (COPD) is a common respiratory disorder with
significant morbidity and mortality. Despite its prevalence, COPD is underdiagnosed, and …

Future directions in the pharmacologic therapy of chronic obstructive pulmonary disease

R Buhl, SG Farmer - Proceedings of the American Thoracic Society, 2005 - atsjournals.org
Current therapy for chronic obstructive pulmonary disease (COPD) fails to alter its relentless
progression. This remains a significant challenge and unmet need. A recent advance is the …