The past decade has seen the emergence of immunotherapy as a prime approach to cancer
treatment, revolutionizing the management of many types of cancer. Despite the promise of …

Cancer cells employ a number of mechanisms to escape immunosurveillance and facilitate
tumour progression. The recent explosion of interest in immunotherapy, especially immune …

Continuously improving knowledge of the fine mechanisms regulating cross-talk between
immune cells, and of their multi-faceted interactions with cancer cells, has prompted the …

The success of immune checkpoint blockade in patients with a wide variety of malignancies
has changed the treatment paradigm in oncology. However, combination therapies with …

Background Epigenetic alterations are known contributors to cancer development and
aggressiveness. Additional to alterations in cancer cells, aberrant epigenetic marks are …

Epigenetic mechanisms, including DNA methylation, histone post-translational
modifications, and chromatin structure regulation, are critical for the interactions between …

Research in two fronts has enabled the development of therapies that provide significant
benefit to cancer patients. One area stems from a detailed knowledge of mutations that …

Epigenetic silencing of immune-related genes is a striking feature of the cancer genome that
occurs in the process of tumorigenesis. This phenomena impacts antigen processing and …

The most exciting recent advance for achieving durable management of advanced human
cancers is immunotherapy, especially the concept of immune checkpoint blockade …

Over the past 25 years, research in cancer therapeutics has largely focused on two distinct
lines of enquiry. In one approach, efforts to understand the underlying cell-autonomous …