Nanotopographical cues of bone implant surface has direct influences on various cell types
during the establishment of osseointegration, a prerequisite of implant bear-loading. Given …

We examined the effect of a nanoscale titanium surface topography (D) versus two hybrid
micro/nanoscale topographies (B and OS) on adherent mesenchymal stem cells (MSCs) …

Bone defect repair is a complex process of bone regeneration. Bone substitute implanted at
the bone defect sites act as three-dimensional scaffolds that guide and promote bone …

The early cell and tissue interactions with nanopatterned titanium implants are insufficiently
described in vivo. A limitation has been to transfer a pre-determined, well-controlled …

Immune cells play vital roles in regulating bone dynamics. Successful bone regeneration
requires a favourable osteo-immune environment. The high plasticity and diversity of …

Advances in nanotechnology open up new possibilities to produce biomimetic surfaces that
resemble the cell in vivo growth environment at a nanoscale level. Nanotopographical …

The aim of our study was to investigate the osteoinductive potential of a titanium (Ti) surface
with nanotopography, using mesenchymal stem cells (MSCs) and the mechanism involved …

The use of endosseous implanted materials is often limited by undesirable effects that may
be due to macrophage-related inflammation. The purpose of this study was to fabricate a …

Nanostructured surfaces feature promising biological properties on biomaterials attracting
large interest at basic research, implant industry development, and bioengineering …

Osteoimmunomodulation has informed the importance of modulating a favorable
osteoimmune environment for successful materials-mediated bone regeneration …