[HTML][HTML] Deciphering the therapeutic resistance in acute myeloid leukemia

C Gurnari, S Pagliuca, V Visconte - International journal of molecular …, 2020 - mdpi.com
Acute myeloid leukemia (AML) is a clonal hematopoietic disorder characterized by abnormal
proliferation, lack of cellular differentiation, and infiltration of bone marrow, peripheral blood …

Novel therapeutic strategies for AML in 2012

MS Tallman - Hematology, 2012 - Taylor & Francis
During the last four decades, much progress has been made in understanding the molecular
pathogenesis of acute myeloid leukemia and in identifying prognostic factors predictive of …

[HTML][HTML] Precision therapy for acute myeloid leukemia

X Yang, J Wang - Journal of hematology & oncology, 2018 - Springer
Acute myeloid leukemia (AML) is a molecularly and clinically heterogeneous disease.
Despite advances in understanding the pathogenesis of AML, the standard therapy …

Advances in the treatment of acute myeloid leukemia: new drugs and new challenges

NJ Short, M Konopleva, TM Kadia, G Borthakur… - Cancer discovery, 2020 - AACR
The therapeutic armamentarium of acute myeloid leukemia (AML) has rapidly expanded in
the past few years, driven largely by translational research into its genomic landscape and …

The rocky road to personalized medicine in acute myeloid leukaemia

B Brinda, I Khan, B Parkin… - Journal of cellular and …, 2018 - Wiley Online Library
Acute myeloid leukaemia (AML) is a malignant disorder of the myeloid blood lineage
characterized by impaired differentiation and increased proliferation of hematopoietic …

Molecular changes during acute myeloid leukemia (AML) evolution and identification of novel treatment strategies through molecular stratification

E Karjalainen, GA Repasky - … in molecular biology and translational science, 2016 - Elsevier
Acute myeloid leukemia (AML) is a hematopoietic malignancy characterized by impaired
differentiation and uncontrollable proliferation of myeloid progenitor cells. Due to high …

[PDF][PDF] New drug approvals in acute myeloid leukemia: an unprecedented paradigm shift

NE Kopmar, EH Estey - Clin Adv Hematol Oncol, 2019 - hematologyandoncology.net
We are witnessing an unprecedented paradigm shift in the treatment of acute myeloid
leukemia (AML). For nearly 4 decades—since the introduction of cytarabine-and …

Current and emerging molecular and epigenetic disease entities in acute myeloid leukemia and a critical assessment of their therapeutic modalities

X Zhao, H Liu, LN Wang, L Yang, X Liu - Seminars in Cancer Biology, 2022 - Elsevier
Acute myeloid leukemia (AML) is the most frequently diagnosed acute leukemia, and its
incidence increases with age. Although the etiology of AML remains unknown, exposure to …

Understanding the molecular basis of acute myeloid leukemias: where are we now?

AM Gruszka, D Valli, M Alcalay - International journal of …, 2017 - Future Medicine
Although the treatment modalities for acute myeloid leukemia (AML) have not changed
much over the past 40 years, distinct progress has been made in deciphering the basic …

[HTML][HTML] Emerging agents and regimens for AML

H Liu - Journal of hematology & oncology, 2021 - Springer
Until recently, acute myeloid leukemia (AML) patients used to have limited treatment options,
depending solely on cytarabine+ anthracycline (7+ 3) intensive chemotherapy and …