ABSTRACT RNA polymerase II (Pol II) pausing at promoter-proximal regions is a highly
regulated step in the transcription cycle. Pause release is facilitated by the P-TEFb kinase …

The transition of RNA polymerase II (Pol II) from transcription initiation into productive
elongation in eukaryotic cells is regulated by the P-TEFb kinase, which phosphorylates the …

Release of RNA polymerase II (Pol II) from promoter-proximal pausing has emerged as a
critical step regulating gene expression in multicellular organisms. The transition of Pol II …

The transition from transcription initiation to elongation at promoters of primary response
genes (PRGs) in metazoan cells is controlled by inducible transcription factors, which utilize …

The ability for the eukaryotic cell to transcriptionally respond to various stimuli is critical for
the overall homeostasis of the cell, and in turn, the organism. The human RNA polymerase II …

Transcription elongation programs are vital for the precise regulation of several biological
processes. One key regulator of such programs is the P-TEFb kinase, which phosphorylates …

Transcription progression is governed by multitasking regulators including SPT5, an
evolutionarily conserved factor implicated in virtually all transcriptional steps from enhancer …

Promoter-proximal pausing by RNA polymerase II (Pol II) ensures gene-specific regulation
and RNA quality control. Structural considerations suggested a requirement for initiation …

Reversible phosphorylation of Pol II and accessory factors helps order the transcription
cycle. Here, we define two kinase-phosphatase switches that operate at different points in …

Promoter-proximal pausing of RNA polymerase II (Pol II) is a major checkpoint in
transcription. An unbiased search for new human proteins that could regulate paused Pol II …