Infections are a major problem in patients with burn diseases. Mortality is high despite
antibiotic therapy as studies are controversial concerning drug underdosing. The aims of this …

Background and objective: Sub-therapeutic dosing of piperacillin-tazobactam in critically-ill
patients is associated with poor clinical outcomes and may promote the emergence of drug …

When piperacillin/tazobactam has been used to treat hospitalized patients with serious
infections, including nosocomial pneumonia caused by Pseudomonas aeruginosa, it has …

The primary objectives of this analysis were to determine which pharmacokinetic model
most accurately describes the elimination pathways for piperacillin in the presence of …

Critical illness caused by burn and sepsis is associated with pathophysiologic changes that
may result in the alteration of pharmacokinetics (PK) of antibiotics. However, it is unclear if …

The objectives of this study were the identification in (morbidly) obese and nonobese
patients of (i) the most appropriate body size descriptor for fosfomycin dose adjustments and …

Background: Although intermittent bolus dosing is currently the standard of practice for many
antimicrobial agents, beta-lactams exhibit time-dependent bacterial killing. Maximizing the …

Purpose To determine whether augmented renal clearance (ARC) impacts negatively on
piperacillin-tazobactam unbound concentrations in critically ill patients receiving 16 g/2 …

Piperacillin in combination with tazobactam is one of the most commonly used intravenous
antibiotics. There is evidence for a possible saturable elimination of piperacillin. Therefore …

Results Sixty-eight participants had data for analysis. Regardless of infusion duration, 6 g/d
piperacillin was associated with≤ 45% target attainment, whereas 12 g/d was associated …