In der vorliegenden Arbeit wurde die Wirkung bakterieller Proteintoxine auf humane
neutrophile Granulozyten untersucht. Dabei wurde mit den clostridialen Toxinen C2 und C3 …

Die vorliegende Arbeit behandelt die Generierung und Charakterisierung rekombinanter
Aktin-modifizierender Fusionstoxine mit dem Ziel der selektiven Inhibition der Chemotaxis …

C. botulinum C2 toxin and C. perfringens iota toxin belong to the family of actin-ADP-
ribosylating toxins that transfer ADP-ribose from NAD to arginine-l77 of actin. This …

Bacterial protein toxins became valuable molecular tools for the targeted modulation of cell
functions in experimental pharmacology and attractive therapeutics because of their potent …

Clostridium botulinum C2 toxin is a member of the family of binary actin-ADP-ribosylating
toxins. It consists of the enzyme component C2I, and the separated binding/translocation …

Several bacterial protein toxins, including C lostridium botulinum C2 toxin, Clostridum
perfringens iota toxin, Clostridium difficile ADP-ribosyltransferase, and the Bacillus …

We have purified from Clostridium spiroforme strain 246 an heterogenous population of
proteins (S a) ranging from 43 to 47 kilodaltons exhibiting ADP-ribosyl transferase activity as …

The C3 enzymes from Clostridium (C.) botulinum (C3bot) and Clostridium limosum (C3lim)
are single chain protein toxins of about 25 kDa that mono-ADP-ribosylate Rho-A,-B, and-C …

Publisher Summary This chapter focuses on the modifications of small GTP-binding proteins
by bacterial protein toxins. Rho GTP-binding proteins belong to the p21 Ras superfamily …

Binary bacterial toxins are unique AB-type toxins, composed of two non-linked proteins that
act as a binding/translocation component and an enzyme component. All known actin-ADP …