Deciphering the combination principles of Traditional Chinese Medicine from a systems pharmacology perspective based on Ma-huang Decoction

Y Yao, X Zhang, Z Wang, C Zheng, P Li… - Journal of …, 2013 - Elsevier
Ethnopharmacology relevance The main therapeutic concept in Traditional Chinese
Medicine (TCM) is herb formula, which treats various diseases via potential herb interactions …

[HTML][HTML] A novel strategy for decoding and validating the combination principles of huanglian jiedu decoction from multi-scale perspective

KX Wang, Y Gao, WX Gong, XF Ye, LY Fan… - Frontiers in …, 2020 - frontiersin.org
Traditional Chinese medicine (TCM) formulas treat complex diseases through combined
botanical drugs which follow specific compatibility rules to reduce toxicity and increase …

[HTML][HTML] Translating traditional herbal formulas into modern drugs: a network-based analysis of Xiaoyao decoction

D Zhang, Y Zhang, Y Gao, X Chai, R Pi, G Chan, Y Hu - Chinese medicine, 2020 - Springer
Abstract Background Traditional Chinese medicine (TCM) encompasses numerous herbal
formulas which play critical therapeutic roles through “multi-components, multi-targets and …

Systems pharmacology-based approach for dissecting the addition and subtraction theory of traditional Chinese medicine: an example using Xiao-Chaihu-Decoction …

B Li, W Tao, C Zheng, PA Shar, C Huang, Y Fu… - Computers in Biology …, 2014 - Elsevier
Background Addition and subtraction theory (AST), a basic theory of herb combination in
traditional Chinese medicine (TCM), is often used to add or subtract the “fundamental …

[HTML][HTML] Systems Pharmacology Dissection of Multi-Scale Mechanisms of Action of Huo-Xiang-Zheng-Qi Formula for the Treatment of Gastrointestinal Diseases

M Zhao, Y Chen, C Wang, W Xiao, S Chen… - Frontiers in …, 2019 - frontiersin.org
Multi-components Traditional Chinese Medicine (TCM) treats various complex diseases
(multi-etiologies and multi-symptoms) via herbs interactions to exert curative efficacy with …

[HTML][HTML] An integrative strategy for discovery of functional compound combination from Traditional Chinese Medicine: Danhong Injection as a model

Z Wang, H Wan, X Tong, Y He, J Yang, L Zhang… - Biomedicine & …, 2021 - Elsevier
Abstract Traditional Chinese Medicine formulas, which are usually considered exerting their
holistic clinical benefits via multi-component, multi-target manner, are unique resources for …

[HTML][HTML] Material basis of Chinese herbal formulas explored by combining pharmacokinetics with network pharmacology

L Pei, Y Bao, S Liu, J Zheng, X Chen - Plos one, 2013 - journals.plos.org
The clinical application of Traditional Chinese medicine (TCM), using several herbs in
combination (called formulas), has a history of more than one thousand years. However, the …

[HTML][HTML] A network pharmacology-based approach to analyse potential targets of traditional herbal formulas: an example of Yu Ping Feng decoction

H Zuo, Q Zhang, S Su, Q Chen, F Yang, Y Hu - Scientific Reports, 2018 - nature.com
Herbal formulas from traditional Chinese medicines (TCMs) have been extensively used in
clinics as effective therapies, but it is still a great challenge to demonstrate the scientific …

[HTML][HTML] Systems pharmacology exploration of botanic drug pairs reveals the mechanism for treating different diseases

W Zhou, J Wang, Z Wu, C Huang, A Lu, Y Wang - Scientific reports, 2016 - nature.com
Multi-herb therapy has been widely used in Traditional Chinese medicine and tailored to
meet the specific needs of each individual. However, the potential molecular or systems …

Potentiating therapeutic effects by enhancing synergism based on active constituents from traditional medicine

A Zhang, H Sun, X Wang - Phytotherapy Research, 2014 - Wiley Online Library
Shifting current drug discovery tide from 'finding new drugs' to 'screening natural products'
may be helpful for overcoming the 'more investment, fewer drugs' challenge. Traditional …